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A complexidade da tarefa como variável da dose do exercício físico na promoção da funcionalidade em mulheres idosas: Brain Functional Training

2026-07-27T16:18:28Z

Título: A complexidade da tarefa como variável da dose do exercício físico na promoção da funcionalidade em mulheres idosas: Brain Functional Training Autor(es): Monteiro, Marcos Raphael Pereira Abstract: Physical exercise is one of the most widespread health practices worldwide, and its prescription has traditionally been guided by classical dose variables such as volume and intensity. However, task complexity has emerged as a relevant component for both movement analysis and physical training, although it still lacks greater theoretical and empirical density. In this context, a training model known as Brain Functional Training (BFT) arises from the premise of increasing task complexity to enhance the activation of brain areas related to movement planning. Accordingly, this thesis investigated the effects and possible mechanisms of manipulating task complexity on the functionality of physically independent older women. In Study I, a theoretical framework was developed, based on a literature review, to support complexity as a variable of exercise dose. The hypothesis was that increasing complexity expands planning demands, elevates acute cognitive load, and more intensely recruits prefrontal regions associated with executive functions, thereby promoting functional adaptations when applied repeatedly. In Study II, the acute effects of different levels of complexity in a squat task were examined on markers of cognitive effort, physical performance, and executive performance in older women. An increase in cognitive effort was observed under more complex conditions, particularly when the squat task was combined with mental calculation or involved unilateral predominance. Despite the higher cognitive cost, no immediate differences were identified between conditions for executive performance. In contrast, increased complexity resulted in longer execution time, reduced movement velocity, and, when complexity was predominantly motor, reduced range of motion. Perceived exertion did not differ between conditions. In Study III, the effects of a 16-week intervention with BFT, functional training, and mind–body interventions were investigated, as well as retention after 16 weeks of detraining, on functionality, executive function, and body composition. All three models promoted similar improvements in functional and executive performance, with partial maintenance after detraining. BFT showed specific advantages in movement under dual-task conditions and inhibitory control, suggesting potential superiority in cognitive demands integrated with movement. All groups also increased appendicular lean mass post-intervention, with a partial decline during the detraining period. It is concluded that task complexity constitutes a promising variable of exercise dose, with acute effects on cognitive effort and motor performance, as well as relevant repeated effects on functionality and cognition in older women.

Efeito da membrana de alginato de sódio contendo extrato hidroalcoólico de Solanum stipulaceum Will na cicatrização de feridas cutâneas excisionais induzidas em camundongos

2026-07-09T19:02:57Z

Título: Efeito da membrana de alginato de sódio contendo extrato hidroalcoólico de Solanum stipulaceum Will na cicatrização de feridas cutâneas excisionais induzidas em camundongos Autor(es): Biano, Laíza Santos Abstract: Wounds represent an important public health problem, affecting quality of life and impacting 1%-2% of the population in developed countries. Given the high cost and limited effectiveness of conventional treatments, there has been growing interest in innovative therapies, such as polymer-based dressings associated with natural bioactive compounds with antioxidant and anti-inflammatory properties. In this context, medicinal plants stand out as a widely used therapeutic alternative. Based on this issue, the present study aimed to evaluate the woundhealing potential of sodium alginate membranes incorporated with hydroalcoholic extract of Solanum stipulaceum in cutaneous wounds induced in mice. For this purpose, alginate membranes (Alg) containing different concentrations of the extract (Alg+Sol 0.25%, 0.5%, and 1%) were developed and characterized for contact angle, mechanical properties, and antioxidant activity. The membranes exhibited adequate mechanical properties, with contact angles below 90° and increased mechanical resistance as the concentration of the incorporated extract increased. In addition, in vitro antioxidant activity was observed, as evidenced by the reduction of DPPH and ABTS radicals. Based on the physicochemical and antioxidant results, the membrane containing 1% extract (Alg+Sol 1%) was selected for in vivo analyses to evaluate its wound-healing potential. After approval by the Animal Research Ethics Committee (No. 1344060422), excisional wounds were induced in mice and treated topically with Alg or Alg+Sol (1%) membranes. The control group received no treatment (NT). Wound healing progression was measured on days 0, 3, 7, 10, and 14 after induction. On day 7, a higher wound closure rate was observed in the Alg+Sol (1%) group compared to the NT (-20.15%; p < 0.05) and Alg (-19.76%; p < 0.0001) groups, with the significant difference maintained until day 10 for the Alg+Sol (1%) group compared to the Alg group (-11.50%; p < 0.05).This effect was accompanied by a reduction in interleukin (IL)-1β levels in the Alg+Sol (1%) group on day 3 (53.23 pg/mg; p < 0.05 vs. NT) and on day 7 (26.91 pg/mg; p < 0.05 vs. NT; 37.44 pg/mg; p < 0.01 vs. Alg), as well as an increase in vascular endothelial growth factor (VEGF) expression (0.371 relative variation; p < 0.01 vs. Alg).On day 10, the Alg+Sol (1%) group also showed a significant reduction in total hydroperoxide levels (0.11 µmol/µL; p < 0.05 vs. Alg), indicating antioxidant activity. Histological analyses performed on days 7 and 14 revealed evidence of reepithelialization and collagen deposition in the Alg+Sol (1%) group, which also showed higher histological grading compared with the NT group on day 14 (p < 0.05). These results indicate that Alg+Sol membranes were prepared with favorable properties for wound-healing applications and demonstrated healing activity in cutaneous wounds, possibly through modulation of inflammation and antioxidant activity, making them a promising biomaterial alternative for wound treatment.

Dor e função na doença de Parkinson: uma abordagem multimetodológica integrando análise clínica, neurofisiológica e intervenção associada ao forró

2026-07-09T18:53:30Z

Título: Dor e função na doença de Parkinson: uma abordagem multimetodológica integrando análise clínica, neurofisiológica e intervenção associada ao forró Autor(es): Jesus, Beatriz Menezes de Abstract: Introduction: Parkinson's disease (PD) presents both motor and non-motor symptoms, such as gait impairments and pain, which are associated with alterations in cortical electrical activity identifiable via electroencephalogram (EEG). Despite the known benefits of dance, gaps persist regarding the standardization of protocols and the availability of physiological data in PD following dance interventions. Objective: To investigate the correlation between pain and function, evaluate the feasibility of an intervention protocol based on Forró (a Brazilian dance genre), and analyze the brain activity of individuals with PD. Methods: Three distinct studies were conducted to address the proposed objectives, as follows: 1) a cross-sectional observational study, following the STROBE checklist, which evaluated pain (Brief Pain Inventory [BPI]) and gait (Timed Up and Go [TUG], 6-Minute Walk Test [6MWT], and Freezing of Gait [FOG]); 2) a feasibility study, which followed the CONSORT recommendations, evaluating the feasibility and acceptability of the Forró-based dance intervention protocol through adherence, satisfaction, refusal rate, data completeness rate, consent rate, adverse events, and clinical changes before and after the intervention (BPI, FOG, 6MWT, and TUG); 3) A single-arm, before-and-after, quasi-experimental study using EEG for the analysis of cerebral activity in individuals with PD prior to and 12 weeks following a Forró-based dance protocol. Recruitment was conducted via social media and included adults and older adults with PD of both sexes, with no age limit, under neurological follow-up, on stable medication, and capable of standing and walking independently (Hoehn & Yahr stages 1 to 4). Results: 1) Positive correlations were found between PD stage and functional capacity (TUG; p < 0.05; ρ = 0.40) and freezing of gait (FOG; p < 0.05; ρ = 0.34); between freezing of gait and pain (FOG and pain interference; p < 0.05; ρ = 0.37); and between pain intensity and pain interference (p < 0.001; ρ = 0.64). Negative correlations were observed between the distance covered in the 6MWT and freezing of gait measured by the FOG (p < 0.001; ρ = -0.67), and between distance covered (6MWT) and pain interference (p < 0.01; ρ = -0.48). 2) The Forró dance protocol proved to be feasible, acceptable, and achieved high participant satisfaction. 3) a reduction in the global slowing of brain activity and alpha band asymmetry was observed. There was an increase in the absolute power of alpha, beta, and gamma bands at Cz and Oz, as well as better energy distribution at Cz. Conclusion: This research demonstrated that: 1. pain interference can compromise functionality in PD; 2. the Forró-based intervention protocol is feasible, acceptable, safe, and replicable; 3. the intervention enhanced alertness and interhemispheric communication. It is concluded that the proposed intervention has the potential to promote integrated clinical and neurophysiological benefits, establishing itself as an promising rehabilitation strategy.

Efeitos neuroprotetor e anti-inflamatório da seda de milho (Stigma maydis)

2026-07-07T17:31:25Z

Título: Efeitos neuroprotetor e anti-inflamatório da seda de milho (Stigma maydis) Autor(es): Souza, Daniel Alves de