https://ri.ufs.br/jspui/handle/riufs/2457 Tue, 07 Jul 2026 23:32:48 GMT 2026-07-07T23:32:48Z http://ri.ufs.br:80/retrieve/ef42025a-0376-4612-b30f-29dbd1b5bc59/PPGCF.jpg https://ri.ufs.br/jspui/handle/riufs/2457 https://ri.ufs.br/jspui/handle/riufs/25253 Título: Canabidiol para controle glicêmico em Diabetes Mellitus: uma revisão sistemática e meta-análise Autor(es): Souza, Jessiane Bispo de Abstract: The loss of pancreatic beta cell function, associated with insulin resistance, contributes to the persistent hyperglycemia characteristic of Diabetes Mellitus (DM). This glycemic dysregulation promotes alterations in biochemical markers, such as HbA1c, fasting and postprandial blood glucose, and insulin levels. Although pharmacotherapy is essential for the management of DM, its adverse effects, mainly gastrointestinal and hypoglycemic, can compromise adherence to treatment. In this scenario, cannabidiol (CBD), a phytocannabinoid derived from Cannabis sativa, has demonstrated great therapeutic potential for various conditions, including epilepsy, chronic pain, and DM. Therefore, this systematic review sought to analyze evidence on the use of CBD in the control of hyperglycemia. The search in four databases identified 856 articles, of which 15 studies were selected, 14 preclinical and 1 clinical. Nine preclinical studies demonstrated a reduction in glucose levels, possibly associated with modulation of the endocannabinoid system, especially in the inhibition of anandamide degradation and consequent stimulation of canonical and non-canonical receptors that are also part of metabolic control. A meta-analysis of 14 in vivo studies indicated that CBD significantly decreased blood glucose levels. The studies presented a risk of bias ranging from low to moderate. It is concluded that CBD shows potential for controlling hyperglycemia, although further preclinical and clinical studies are needed to elucidate the mechanisms involved in regulating blood glucose levels and thus guide new therapeutic approaches and research on the subject, serving as supporting material for possible clinical applications. Thu, 26 Feb 2026 00:00:00 GMT https://ri.ufs.br/jspui/handle/riufs/25253 2026-02-26T00:00:00Z https://ri.ufs.br/jspui/handle/riufs/24557 Título: A questão étnico-racial na formação farmacêutica: uma análise curricular das Instituições Federais de Ensino Superior Brasileiras Autor(es): Cavalcante, Nayara Costa Fri, 18 Aug 2023 00:00:00 GMT https://ri.ufs.br/jspui/handle/riufs/24557 2023-08-18T00:00:00Z https://ri.ufs.br/jspui/handle/riufs/24378 Título: Fatores responsáveis pela prevalência global das geohelmintíases: uma overview de revisões sistemáticas Autor(es): Ramos Neto, Adelson Ferreira Abstract: It is estimated that more than 1.5 billion people are infected with at least one soiltrasmitted helminth. Although the prevalence of geohelminthiasis and its associatedfactors have been studied over the years, this parasitosis is classified by the WorldHealth Organization (WHO) as Neglected Tropical Disease. Systematic review studieson the subject collect information on infection rates and associated factors in severalcountries. The objective of this overview of systematic reviews is to discuss howenvironmental factors, host-related risk factors, and control strategies influence theprevalence of soil-transmitted helminths in different regions of the world. The followingdatabases were used: LILACS, PubMed, Web of Knowlegde, Embase and TheCochrane Library and Clinical Trials (gray literature). In each of these databases thefollowing descriptors were used: helminths, geohelminths, soil-transmitted helminths, epidemiology, prevalence, Ascaris lumbricoides, Trichuris trichiura, Necatoramericanus, Ancylostoma duodenale, systematic review. Systematic reviews wereincluded, with or without meta-analysis, published until December 2017 and theinclusion criteria were: (i) to present a clear research question and eligibility criteriaused for the selection of the studies; (ii) describe all the sources of information in thesearch and the keywords used; (iii) present the number of studies found in the sources ofinformation and included in the final sample of the systematic review. The evaluation ofthe quality of the studies was done using the AMSTAR tool (Assessing theMethodological Quality of Systematic Reviews). The initial results of the bibliographicsearch identified 1,448 articles of which 125 were excluded by simultaneous indexing intwo or more databases. After review reviews, 17 met the inclusion criteria and wereused in this overview. Factors such as climate, MDA (Mass Drug Administration), WASH (Water, Sanitation and Hygiene) access, shoe use and nutritional status wereconsidered to be the main culprits for the prevalence rate of geohelminthiases. AlthoughWHO strategies to reduce the prevalence of geohelminthias have a positive short-termeffect, it is necessary to understand other aspects, such as socioeconomic and culturalfactors, to achieve satisfactory rates of prevalence. Fri, 23 Aug 2019 00:00:00 GMT https://ri.ufs.br/jspui/handle/riufs/24378 2019-08-23T00:00:00Z https://ri.ufs.br/jspui/handle/riufs/23773 Título: Desempenho dos métodos de Kato-Katz e Helmintex para o diagnóstico da esquistossomose mansoni em área endêmica no Estado de Sergipe Autor(es): Menezes, Daniel Lima Abstract: Schistosomiasis is a parasitic infection caused by the helminth Schistosoma mansoni and represents a serious public health problem in tropical regions, affecting more than 250 million people worldwide. In Sergipe, the disease is endemic and affects more than 65% of the state's municipalities. The Schistosomiasis Control Program (SCP) uses the Kato-Katz (KK) method for population screening, as recommended by the World Health Organization, but there is growing evidence for the sensitivity limitations associated with KK, especially in areas with low parasite loads. Helmintex (HTX) is a sensitive egg detection method based on the magnetic properties of S. mansoni eggs and their isolation in a magnetic field. The aim of this study is to evaluate both KK and HTX in an endemic area for schistosomiasis in Sergipe, Areia Branca, located in the municipality of Pacatuba. Individuals from six years older who signed the term of consent and/or free and informed assent and who provided fecal samples in sufficient quantity to carry out the tests participated in the project. At the end, the results were delivered to the population and all positive individuals were treated. A total of 234 individual fecal samples were delivered and two KK thick smears were prepared and evaluated for each sample. A total of 30g of each fecal sample was processed by the HTX method. Eggs were detected in 80 (34.18%) of the participants. Twenty-three (9.83%) samples were positive by the KK method and 77 (32.91%) by the HTX method. A total of 95.7% (22/23) of the positive samples in the KK method had mild infections and only one individual (4.3%) had a moderate infection (108 OPG, eggs per gram of feces). The age of the sampled population ranged from six to 97 years, with a mean of 35.5 ± 18.1 years. There was no statistical relationship between infection and age (KK vs. AGE -0.442; HTX vs. AGE - 0.543). More than half of the participants were female (56.98%). The gender variable showed that men were more likely to become infected, according to KK (PR: 2.91) and HTX (PR: 1.79) data. The sensitivity of KK was 28.8% while that of HTX was 96.2%. The ROC curve showed that the probability of detecting schistosomiasis is higher with Helmintex (0.98) than with Kato-Katz (0.64). A HTX detects 3.3x more PPV and 25% more NPV. Public policies are necessary to change the panorama of neglected diseases, especially in the control of schistosomiasis in endemic areas. Fri, 22 Sep 2023 00:00:00 GMT https://ri.ufs.br/jspui/handle/riufs/23773 2023-09-22T00:00:00Z