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Document Type: Artigo
Title: Differential effects of lead and zinc on inhibitory avoidance learning in mice
Authors: Oliveira, Fábio S. de
Santos, Márcio Roberto Viana dos
Antoniolli, Ângelo Roberto
Marchioro, Murilo
Issue Date: Jan-2002
Abstract: We studied the effects of chronic intoxication with the heavy metals lead (Pb2+) and zinc (Zn2+) on memory formation in mice. Animals were intoxicated through drinking water during the pre- and postnatal periods and then tested in the step-through inhibitory avoidance memory task. Chronic postnatal intoxication with Pb2+ did not change the step-through latency values recorded during the 4 weeks of the test (ANOVA, P>0.05). In contrast, mice intoxicated during the prenatal period showed significantly reduced latency values when compared to the control group (day 1: q = 4.62, P<0.05; day 7: q = 4.42, P<0.05; day 14: q = 5.65, P<0.05; day 21: q = 3.96, P<0.05, and day 28: q = 6.09, P<0.05). Although chronic postnatal intoxication with Zn2+ did not alter a memory retention test performed 24 h after training, we noticed a gradual decrease in latency at subsequent 4-week intervals (F = 3.07, P<0.05), an effect that was not observed in the control or in the Pb2+-treated groups. These results suggest an impairment of memory formation by Pb2+ when the animals are exposed during the critical period of neurogenesis, while Zn2+ appears to facilitate learning extinction.
Keywords: Chumbo
Esquiva inibitória
ISSN: 1414-431X
Publisher / Institution : Brazilian Journal of Medical and Biological Research
Citation: OLIVEIRA F. S. et al. Differential effects of lead and zinc on inhibitory avoidance learning in mice. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 34, n. 1, jan. 2001. Disponível em: <>. Acesso em: 08 de set. 2014.
License: Creative Commons Attribution License
Appears in Collections:DFS - Artigos de periódicos

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