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Tipo de Documento: Artigo
Título : Bioassay-guided evaluation of central nervous system effects of citronellal in rodents
Autor : Melo, Mônica Santos de
Souza, Marilia Trindade de Santana
Guimarães, Adriana Gibara
Barreto, Rosana de Souza Siqueira
Barreto, Rosana de Souza Siqueira
Quintans-Júnior, Lucindo José
Santos, Márcio Roberto Viana dos
Bonjardim, Leonardo Rigoldi
Araújo, Adriano Antunes de Souza
Onofre, Alexandre Sherlley Casimiro
Lima, Julianeli Tolentino de
Almeida, Jackson Roberto Guedes da Silva
Fecha de publicación : ago-2011
Resumen : The central nervous system (CNS) depressant and anticonvulsant activities of citronellal (CT) were investigated in animal models. The CT in doses of 100, 200 and 400 mg/kg injected by i.p. route in mice caused a significant decrease in the motor activity of animals when compared with the control group. The highest dose of CT significantly reduced the remaining time of the animals on the Rota-rod apparatus up to 2 h. Additionally, CT at doses 100, 200 and 400 mg/ kg (i.p.) was also capable to promote an increase of latency for development of convulsions induced by pentylenetetrazole (PTZ). It was efficient in prevents the tonic convulsions induced by maximal electroshock (MES) in doses of 200 and 400 mg/kg, resulting in 30 and 40% of protection, respectively. This compound was also capable to promote an increase of latency for development of convulsions induced by picrotoxin (PIC) at 400 mg/kg. In the same way, the anticonvulsant effect of CT was affected by pretreatment with flumazenil, a selective antagonist of benzodiazepine site of GABAA receptor. These results suggest a possible CNS depressant and anticonvulsant activities.
Palabras clave : Atividade anticonvulsivante
Citronela
Monoterpenos
Atividade depressora
ISSN : 0102-695X
Citación : MELO, M. S. et al. Bioassay-guided evaluation of central nervous system effects of citronellal in rodents. Revista Brasileira de Farmacognosia, Curitiba, v. 21, n. 4, Ago. 2011. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000400020&lng=en&nrm=iso>. Acesso em: 7 jun. 2013.
License: Creative Commons Attribution License
URI : https://ri.ufs.br/handle/riufs/589
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DFA - Artigos de periódicos

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