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Tipo de Documento: Artigo
Título : Chemical composition and cytotoxic activity of the essential oil from the leaves of Casearia lasiophylla
Autor : Salvador, Marcos José
Carvalho, João Ernesto de
Wisniewski Junior, Alberto
Kassuya, Cândida Aparecida Leite
Santos, Élide Pereira dos
Riva, Dilamara
Stefanello, Maria Élida Alves
Fecha de publicación : oct-2011
Resumen : The essential oil obtained by hydrodistillation from fresh leaves of Casearia lasiophylla Eichler, Salicaceae, was analyzed by gas capillary (GC/FID and GC/MS). The cytotoxicity of the leaves essential oil was tested in vitro againstU251 (glioma), UACC-62 (melanoma), MCF-7 (breast), NC1-ADR/RES (ovarian-resistant), NCI-H460 (lung), PC03 (prostate), OVCAR-3 (ovarian), HT-29 (colon) and K562 (leukemia) human cancer cells and against VERO (no cancer cell). The yield of oil was 0.02%. Fifty two compounds were identified, representing 87.1% of the total of the oil. The main components were identified as germacrene D (18.6%), β-caryophyllene (14.7%), δ-cadinene (6.2%), and α-cadinol (5.4%). The oil exhibited antiproliferative activity against all cell lines (TGI<100 µg/mL), with exception of NCI-H460 cell line (TGI 191.31 µg/mL). The highest activity was observed against UACC-62 (TGI 7.30 µg/mL), and K562 (TGI 7.56 µg/mL) cell lines. The observed activity could be related to high content of germacrene D and β-caryophyllene, compounds known as cytotoxic.
Palabras clave : Casearia lasiophylla Eichler
Salicaceae
Óleos essenciais
Citotoxicidade
Atividade anti-tumoral
Germacreno D
ISSN : 0102-695X
Institución / Editorial : Sociedade Brasileira de Farmacognosia
Citación : SALVADOR, M. J. et al. Chemical composition and cytotoxic activity of the essential oil from the leaves of Casearia lasiophylla. Revista Brasileira de Farmacognosia, Curitiba, v. 21, n. 5, p. 864-868, set./out. 2011. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000500013>. Acesso em: 13 ago. 2013.
License: Creative Commons Attribution License
URI : https://ri.ufs.br/handle/riufs/666
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