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Document Type: Monografia
Title: Avaliação da eficácia de nanopartículas contendo pentamidina para o tratamento da Leishmaniose Tegumentar
Other Titles: Evaluation of the efficacy of nanoparticles containing pentamidine for treatment of Leishmaniose Tegumentar
Authors: Santos, Mayara Gois dos
Issue Date: 21-Jan-2018
Advisor: Lira, Ana Amélia Moureira
Abstract: Leishmaniasis are infectious-parasitic diseases caused by protozoa of the genus Leishmania. Treatment is mainly by antimonials. Pentamidine is an alternative for treatment with antimonials, but it is administered by deep intramuscular injection and presents some adverse effects such vomiting, headache and myalgia. Drug delivery systems such as lipid nanoparticles have shown as an interesting alternative to treatment, because they have a smaller particle size, improve bioavailability and can be administered by various routes and improve the efficacy and safety of the drug. Thus, the objective of this study was to obtain nanoparticles containing pentamidine and evaluate them in the treatment of tegumentary leishmaniasis using alternative routes of administration, such as the topical route. Nanostructured Lipid Carriers (NLC) were obtained by w/o/w double emulsion. Size, polydispersity index (IPD), Zeta Potential and encapsulation efficiency of the NLC were determined. Ex vivo cutaneous permeation study, cytotoxicity and leishmanicidal activity of the best formulation were also determined. NLC showed nanometric size from 172 to 266 nm, IPD below 0.5, and encapsulation efficiency of 14 - 75%. NLC 2 have also presented sustained release profile. However, they were not able to promote the skin permeation of the drug. The cytotoxicity of NCL 2 was similar to control (free pentamidine).The leishmanicidal activity was low, where IC50 in promastigotes of the pentamidine from NLC was 7.2 times higher than free pentamidine. Thus, this system is not an alternative for topical treatment.
Keywords: Farmácia
Ensino de farmácia
Leishmaniose Tegumentar
Tegumentary leishmaniasis
Nanostructured lipid carriers
Language: eng
Institution: Universidade Federal de Sergipe
Department: DFA - Departamento de Farmácia – São Cristóvão - Presencial
Citation: SANTOS, Mayara Gois dos. Avaliação da eficácia de nanopartículas contendo pentamidina para o tratamento da Leishmaniose Tegumentar. São Cristóvão, SE, 2018. Monografia (Bacharelado em Farmácia) - Departamento de Farmácia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Sergipe, São Cristóvão, SE, 2018
Appears in Collections:Farmácia

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