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Document Type:	Artigo
Title:	Differential effects of lead and zinc on inhibitory avoidance learning in mice
Authors:	Oliveira, F. S. Santos, Márcio Roberto Viana dos Antoniolli, Ângelo Roberto Marchioro, Murilo
Issue Date:	2001
Resumo :	We studied the effects of chronic intoxication with the heavy metals lead (Pb2+) and zinc (Zn2+) on memory formation in mice. Animals were intoxicated through drinking water during the pre- and postnatal periods and then tested in the step-through inhibitory avoidance memory task. Chronic postnatal intoxication with Pb2+ did not change the step-through latency values recorded during the 4 weeks of the test (ANOVA, P>0.05). In contrast, mice intoxicated during the prenatal period showed significantly reduced latency values when compared to the control group (day 1: q = 4.62, P<0.05; day 7: q = 4.42, P<0.05; day 14: q = 5.65, P<0.05; day 21: q = 3.96, P<0.05, and day 28: q = 6.09, P<0.05). Although chronic postnatal intoxication with Zn2+ did not alter a memory retention test performed 24 h after training, we noticed a gradual decrease in latency at subsequent 4-week intervals (F = 3.07, P<0.05), an effect that was not observed in the control or in the Pb2+-treated groups. These results suggest an impairment of memory formation by Pb2+ when the animals are exposed during the critical period of neurogenesis, while Zn2+ appears to facilitate learning extinction.
Keywords:	Lead Zinc Inhibitory avoidance Memory Chumbo Zinco Memória
ISSN:	0100-879X 1414-431X
Is part of:	Brazilian Journal of Medical and Biological Research
Language:	eng
Publisher / Institution :	Associação Brasileira de Divulgação Científica
Citation:	OLIVEIRA, F. S. et al. Differential effects of lead and zinc on inhibitory avoidance learning in mice. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 34, n. 1, p. 117-120, jan. 2001. Disponível em: https://www.scielo.br/j/bjmbr/a/dNhKDzsnyBCBdpDXfZdWHjh/?format=pdf&lang=en. Acesso em: 15 out. 2024.
License:	Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)
URI:	https://ri.ufs.br/jspui/handle/riufs/20282
Appears in Collections:	DFS - Artigos de periódicos

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