Avaliação da concordância entre dois métodos não invasivos (APRI e Fibroscan) para diagnóstico de fibrose hepática em pacientes com hepatites virais B e C

Abstract

The long term viral hepatitis and liver fibrosis are linked. Studies suggests, however, that liver fibrosis is reversible, what emphasizes the assessment in an early stage, and monitor that during the follow-up. Considering this, the objective of this study was to evaluate the concordance between two non-inavasive methods to asses liver fibrosis in HBV and HCV chronic infected pacients. The study was composed by 31 HBV patients, and 45 HCV. The patient’s hospital records were analyzed to collect information about sex, body mass index (BMI) and laboratorial data to analyze the biochemical markers. The liver fibrosis assessment was made using the two methods APRI and Fibroscan (Kpa) and compared the concordance between them using the Spearman test. As results, we had predominance of the masculine sex (64,4%) between HCV pacients and HBV pacients (54,8%). HCV infected pacients presented age average (54,8 years), and elevated measurement of AST and ALT. We observed positive correlation between APRI and Fibroscan in HCV pacients and the two hepatitis combined. The study results suggest that the non-invasive methods to assess and monitor the liver fibrosis presented strong correlation, especially in HCV patients.