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Document Type:	Artigo
Title:	Lycopene and ß-carotene protect in vivo iron-induced oxidative stress damage in rat prostate
Authors:	Matos, Humberto Reis Marques, Sabrina de Almeida Gomes, Osmar Francisco Silva, Alexandre Alves da Heimann, Joel Claudio Di Mascio, Paolo Medeiros, Marisa Helena Gennari de
Issue Date:	2006
Resumo :	It has been suggested that iron overload may be carcinogenic. In the present study, we evaluated the effect of plasma and prostate carotenoid concentration on oxidative DNA damage in 12-week-old Wistar rats treated with intraperitoneal (ip) ferric nitrilotriacetate (Fe-NTA) (10 mg Fe/kg). Plasma ß-carotene and lycopene concentrations were measured as a function of time after ip injection of carotenoids (10 mg kg-1 day-1 ß-carotene or lycopene) in rats. The highest total plasma concentration was reached 3 and 6 h after ip injection of lycopene or ß-carotene, respectively. After 5 days of carotenoid treatment, lycopene and ß-carotene were present in the 0.10-0.51 nmol/g wet tissue range in the prostate. Using a sensitive method to detected 8-oxo-7,8- dihydro-2'-deoxyguanosine (8-oxodGuo) by HPLC/EC, the level of 8-oxodGuo in rat prostate DNA was significantly higher (6.3 ± 0.6 residues/106 dGuo) 3 h after Fe-NTA injection compared with control rats (1.7 ± 0.3 residues/106 dGuo). Rats supplemented with lycopene or ß-carotene for 5 days prior to Fe-NTA treatment showed a reduction of about 70% in 8-oxodGuo levels to almost control levels. Compared with control rats, the prostate of Fe-NTA-treated animals showed a 78% increase in malondialdehyde accumulation. Lycopene or ßcarotene pre-treatment almost completely prevented lipid damage. Epidemiological studies have suggested a lower risk of prostate cancer in men reporting a higher consumption of tomato products. However, before associating this effect with tomato sauce constituents, more information is required. The results described here may contribute to the understanding of the protective effects of carotenoids against iron-induced oxidative stress.
Keywords:	Lycopene ß-carotene DNA damage 8-oxo-7,8-dihydro-2'-deoxyguanosine Ferric nitrilotriacetate Prostate cancer Câncer de próstata Licopeno Betacaroteno
ISSN:	0100-879X 1414-431X
Is part of:	Brazilian Journal of Medical and Biological Research
Language:	eng
Publisher / Institution :	Associação Brasileira de Divulgação Científica
Citation:	MATOS, H. R. et al. Lycopene and ß-carotene protect in vivo iron-induced oxidative stress damage in rat prostate. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 39, n. 2, p. 203-210, fev. 2006. Disponível em: https://www.scielo.br/j/bjmbr/a/BmxwSZZKKww44krKsdJLjKH/?format=pdf&lang=en. Acesso em: 19 nov. 2024.
License:	Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)
URI:	https://ri.ufs.br/jspui/handle/riufs/20472
Appears in Collections:	DFS - Artigos de periódicos

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