Características histopatológicas do carcinoma colorretal em peças cirúrgicas de pacientes jovens e idosos

Abstract

Recently, some studies noticed that the diagnosis of Colorectal Carcinoma, one of the most common and lethal types of cancer, has increased in younger patients. Identifying the characteristics of advanced neoplasms in the population aged ≤ 50 years may help in the development of new preventive and early detection strategies. The relevance of this subject motivated this study to analyze morphological features of CRC in patients ≤ 50 years old and compare them with older than 50 years old. Colectomy specimens from 2012 to 2016 performed for CRC treatment were histologically reviewed and several pathological parameters were taken into consideration. Our analysis indicated that older patients are more likely to have free lymph nodes and no perineural infiltration in comparison to younger patients. On the other hand, tumor stage, size and grade as well as angiolymphatic invasion, surgical margins status and tumor budding did not show any significant difference in both age groups.