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https://ri.ufs.br/jspui/handle/riufs/21123| Document Type: | Artigo |
| Title: | Detection of HPV DNA and immunohistochemical expression of cell cycle proteins in oral carcinoma in a population of brazilian patients |
| Authors: | Soares, Rosilene Calazans Oliveira, Márcio Campos Souza, Lélia Batista de Costa, Antônio de Lisboa Lopes Pinto, Leão Pereira |
| Issue Date: | Oct-2008 |
| Resumo : | This study investigated the presence of human papillomavirus (HPV) DNA and viral types in 33 cases of oral squamous cells carcinoma (OSCC) and compared the immunohistochemical expression of the cell-cycle markers p21 and pRb between cases of the disease with and without HPV. DNA was extracted from paraffin-embedded tissue and amplified by PCR for the detection of HPV DNA. Viral typing was performed by dot blot hybridization. Immunohistochemistry was performed by the streptavidinbiotin technique. HPV DNA was detected in 11 (33.33%) of the 33 cases. The prevalent viral type was HPV 18 (81.81%). A significant association was observed between the presence of HPV and immunohistochemical expression of pRb, but not between p21 expression and the presence of the virus. The low frequency of detection of HPV DNA in OSCC suggests a possible participation of the virus in the development and progression of only a subgroup of these tumors. |
| Keywords: | DNA probes HPV Carcinoma Squamous cell cancer Polymerase chain reaction Hybridization Cell cycle |
| ISSN: | 1678-7757 1678-7765 |
| Is part of: | Journal of Applied Oral Science |
| Language: | eng |
| Publisher / Institution : | Faculdade De Odontologia De Bauru - Universidade de São Paulo |
| Citation: | SOARES, R. C. et al. Detection of HPV DNA and immunohistochemical expression of cell cycle proteins in oral carcinoma in a population of brazilian patients. Journal of Applied Oral Science, Bauru, v. 16, n. 5, p. 340-344, set./out. 2008. Disponível em: https://www.scielo.br/j/jaos/a/DdJNSdWwGydBXQ3wn3rRkDd/?format=pdf. Acesso em: 13 fev. 2025. |
| License: | Creative Commons Atribuição 4.0 Internacional (CC BY 4.0) |
| URI: | https://ri.ufs.br/jspui/handle/riufs/21123 |
| Appears in Collections: | DMO - Artigos de periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| DetectionHPVDNAOralCarcinoma.pdf | 247,04 kB | Adobe PDF |  View/Open |
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