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https://ri.ufs.br/jspui/handle/riufs/21278| Document Type: | Artigo |
| Title: | Estudo de liberação e permeação in vitro do diclofenaco de dietilamônio em microemulsão gel-like |
| Other Titles: | In vitro release and permeation of a diclofenac diethylamine from microemulsion gel-like |
| Authors: | Silva, José Alexsandro da Santana, Davi Pereira de Bedor, Danilo Galindo César Borba, Valeria Ferreira da Costa Lira, Ana Amélia Moreira Egito, Eryvaldo Socrates Tabosa do |
| Issue Date: | 2009 |
| Abstract: | The goal of this study was to produce and characterize a new microemulsion gel-like carrier system (MEG) by using the pseudo-ternary phase-diagram concept. The diclofenac diethylamine (DDA) was incorporated in the MEG and its in vitro release and permeation profiles were performed using Franz-type diffusion cells. The results revealed that the commercial DDA emulgel provided significantly higher Kp of DDA (2.2-fold) as compared to the MEG. Similar data were obtained in the permeation studies in which DDA Kp 4.7-fold higher. Therefore, MEG presents higher potential as a topical delivery system for DDA when compared to the commercial DDA emulgel. |
| Keywords: | Diclofenac diethylamine In vitro release Microemulsion gel-like |
| ISSN: | 0100-4042 1678-7064 |
| Is part of: | Química Nova |
| Language: | por |
| Publisher / Institution : | Sociedade Brasileira de Química |
| Citation: | SILVA, J. A. et al. Estudo de liberação e permeação in vitro do diclofenaco de dietilamônio em microemulsão gel-like. Química Nova, São Paulo, v. 32, n. 6, p. 1389-1393, 2009. Disponível em: https://www.scielo.br/j/qn/a/6bRH5Q56w6fMR7Dbz9YxK6y/?format=pdf&lang=pt. Acesso em: 26 fev. 2025. |
| License: | Creative Commons Atribuição-NãoComercial 4.0 Internacional (CC BY-NC 4.0) |
| URI: | https://ri.ufs.br/jspui/handle/riufs/21278 |
| Appears in Collections: | DFS - Artigos de periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| EstudoDiclofenacoDietilamonio.pdf | 255,31 kB | Adobe PDF |  View/Open |
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