Avaliação do risco de fratura analisado pelo FRAX em pacientes com lupus eritematoso sistêmico

Abstract

INTRODUCTION: Secondary osteoporosis (OPS) is a common complication in patients with Systemic Lupus Erythematosus (SLE) and in the ones using glucocorticoids and for an extended time. The FRAX algorithm enable quantify the probability of having hip fracture (CF) or fracture major (FM) in a period of 10 years, using clinical risk factors associated or not with bone mineral density (BMD). The objective of the study was to evaluate the risk of fractures in women with SLE using the FRAX algorithm. MATERIALS AND METHODS: A quantitative approach and convenience sampling was carried out in patients with SLE. The study included control group (CG), composed of 20 healthy individuals and Lupus Group (GL), composed of 20 patients with SLE. The groups were matched for gender, weight, height, body mass index (BMI). For all study participants, the algorithm FRAX was calculated to assess the risk of osteoporotic fracture, not including the value of bone mineral density. RESULTS: The scores obtained through the FRAX algorithm showed that patients with SLE have a higher risk of hip fracture (GC = 0.2 ± 0.1 vs 0.8 ± 0.1 GL = p = 0.05) and fracture major (GC = 1.2 ± 0.3 vs. 4.2 ± 0.2 GL = p = 0.01) than healthy subjects. CONCLUSIONS: Women with SLE are at increased risk of osteoporotic fracture, when evaluated using the FRAX algorithm.