Microalbuminúria como marcador de lesão renal na anemia falciforme

Abstract

Objectives: To evaluate the prevalence of microalbuminuria in patients with AF and to identify clinical and / or laboratory features associated. Methods: The medical records of patients were reviewed for information on the presence of complications. Held collect blood for laboratory tests. Search microalbuminuria 24 hours was requested. The chi-square or Fisher in the statistical analysis of categorical variables were used. To compare numerical variables between two groups, the Student t test or Mann-Whitney test were used. The level of significance was set to p less than 0.05. Results: In this study, the frequency of microalbuminuria was 19.05% and the mean age of patients with positive microalbuminuria was 14.1 years. The presence of microalbuminuria was significantly related to age and levels of total and indirect bilirubin. The mean creatinine clearance was above the normal range (162.2 ml/min/1, 73m2), revealing hyperfiltration. The presence of microalbuminuria showed significant correlation with the average serum creatinine (p = 0.048). The MA showed hyperfiltration with mean values of creatinine and normal proteinuria. The presence of gallstones was demonstrated a protective factor for the occurrence of MA, while 68.7% of these patients were negative for MA (p = 0.006). Conclusion: Common renal function tests are not reliable in detecting lesions in patients with AF, especially in children and young adults, one should ask the research of microalbuminuria 24 hours. Larger studies involving the presence of MA with clinical and laboratory characteristics are needed.