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https://ri.ufs.br/jspui/handle/riufs/23113| Document Type: | Artigo |
| Title: | Immunohistochemical analysis of Proliferating Cell Nuclear Antigen (PCNA) in dental follicles of impacted third molars |
| Other Titles: | Análisis imunohistoquímico de Antígeno de Proliferación Celular Nuclear (PCNA) en folículos dentales de los terceros molares retenidos |
| Authors: | Oliveira, David Moraes de Silveira, Márcia Maria Ferreira da Andrade, Emanuel Sávio de Souza Sobral, Ana Paula Veras Martins Filho, Paulo Ricardo Saquete |
| Issue Date: | Jun-2011 |
| Resumo : | : This study investigated the immunodetection of PCNA in epithelial components of dental follicles associated with impacted third molars without radiographical and morphological signs of pathosis. A total of 105 specimens of dental follicles associated with impacted third molars with incomplete rhizogenesis (between Nolla’s stage 6 and 9) were surgically removed from 56 patients. Epithelial cell proliferating was determined by using immunohistochemical labeling. Statistical analysis was performed using the Fisher exact test. Of the 105 dental follicles collected, 6 were PCNA-positive (≈ 6%). The specimens with squamous metaplasia and epithelial hyperplasia had higher rates of positivity for PCNA, as well as those with proliferative remnants of odontogenic epithelium. In conclusion, this study shows that dental follicles at this stage of development have low proliferative potential, but suggests that squamous metaplasia, hyperplasia of the epithelial lining and presence of proliferative odontogenic epithelial rests in the connective tissue may be early signs of developing lesions of odontogenic origin. |
| Keywords: | Immunohistochemistry Dental sac Third molar |
| ISSN: | 0717-9502 |
| Is part of: | International Journal of Morphology |
| Language: | eng |
| Publisher / Institution : | Sociedad Chilena de Anatomía |
| Citation: | OLIVEIRA, D. M. et al. Immunohistochemical analysis of Proliferating Cell Nuclear Antigen (PCNA) in dental follicles of impacted third molars. International Journal of Morphology, Temuco, v. 29, n. 2, p. 526-531, jun. 2011. Disponível em: https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000200037&lng=en&nrm=iso&tlng=en. Acesso em: 15 set. 2025. |
| License: | Creative Commons Atribuição-NãoComercial 4.0 Internacional (CC BY-NC 4.0) |
| URI: | https://ri.ufs.br/jspui/handle/riufs/23113 |
| Appears in Collections: | DOD - Artigos de periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| ImmunohistochemicalAnalysisProliferatingCellNuclearAntigen.pdf | 523,24 kB | Adobe PDF |  View/Open |
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