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Document Type:	Artigo
Title:	Acute diarrhoea in a community cohort of children who received an oral rotavirus vaccine in Northeast Brazil
Authors:	Vieira, Sarah Cristina Fontes Gurgel, Ricardo Queiroz Kirby, Andrew Barreto, Isis Pinheiro Souza, Liane Desiderio de Oliveira, Oderlan Carvalho Correia, Jailson de Barros Dove, Winifred Cunliffe, Nigel A. Cuevas, Luis E.
Issue Date:	May-2011
Resumo :	Rotavirus is an important cause of childhood diarrhoea. A monovalent rotavirus vaccine (Rotarix®) was introduced into the Immunization Program of Brazil in 2006. In this study, we describe the incidence and burden of disease of rotavirus diarrhoea in two cohorts of children (vaccinated and unvaccinated). We followed two groups of 250 children under one year old, who were enrolled in December 2006 from a low-income residential area in Northeast Brazil. The children were monitored every two weeks for two years. Stool samples from children with diarrhoea were examined for the presence of rotavirus. Rotaviruses were genotyped using real time-polymerase chain reaction. The mean numbers of all-cause diarrhoea episodes/child (adjusted for age) in the first year were 0.87 and 0.84, in vaccinated and unvaccinated children, respectively. During the second year, the number of episodes/ child decreased to 0.52 and 0.42. Only 16 (4.9%) of 330 stool samples were rotavirus-positive (10 vaccinated and 6 unvaccinated children) and only P[4]G2 rotaviruses were identified. All-cause diarrhoea episodes were more severe in unvaccinated children in the first year of age (p < 0.05), while vaccinated children had more severe episodes 18 months after vaccination. Rotavirus diarrhoea incidence was very low in both groups.
Keywords:	Diarrhoea Rotavirus Vaccine Cohort Children Brazil
ISSN:	1678-8060
Is part of:	Memórias do Instituto Oswaldo Cruz
Language:	eng
Publisher / Institution :	Instituto Oswaldo Cruz - Ministério da Saúde
Citation:	VIEIRA, S. C. F. et al. Acute diarrhoea in a community cohort of children who received an oral rotavirus vaccine in Northeast Brazil, Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 106, n. 3, p. 330-334, maio 2011. Disponível em: https://www.scielo.br/j/mioc/a/BxfxrhkQSkdZLLMP9dLh44x/?lang=en. Acesso em: 24 set. 2025.
License:	Creative Commons Atribuição-NãoComercial 4.0 Internacional (CC BY-NC 4.0)
URI:	https://ri.ufs.br/jspui/handle/riufs/23237
Appears in Collections:	PPGCS - Artigos de periódicos

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