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https://ri.ufs.br/jspui/handle/riufs/23314| Document Type: | Artigo |
| Title: | Immunohistochemical analysis of human homologue of drosophila patched (PTCH) in dental follicles of impacted third molars |
| Other Titles: | Análisis imunohistoquímico del homólogo humano del gen parcheado de drosofila (PTCH) en folículos dentales de terceros molares retenidos |
| Authors: | Oliveira, David Moraes de Silveira, Márcia Maria Ferreira da Andrade, Emanuel Sávio de Souza Sobral, Ana Paula Veras Martins Filho, Paulo Ricardo Saquete Santos, Thiago de Santana Oliveira, Patrícia Leimig Amorim de Peixoto, Aline Carvalho Santos, Jadson Alípio Santana de Souza Piva, Marta Rabello |
| Issue Date: | 2012 |
| Resumo : | This study investigated the immunodetection of PTCH in epithelial components of dental follicles associated with impacted third molars without radiographic signs of pathosis. One hundred and five specimens of dental follicles associated with impacted third molars with incomplete rhizogenesis (between Nolla’s stage 6 and 9) were surgically removed from 56 patients. Epithelial cell proliferation was determined by using immunohistochemical labeling. Statistical analysis was performed using Fisher exact test and a level of significance of 5%. Of the 105 dental follicles collected, 3 were PTCH-positive. The specimens with squamous metaplasia and epithelial hyperplasia had higher rates of positivity for PTCH, as well as those with active remnants of odontogenic epithelium. This study suggests that the odontogenic cells of the dental follicle might be proliferating during the rhizogenesis, while the squamous metaplasia and hyperplasia of the epithelial lining and proliferative odontogenic epithelial rests show the differentiation potential of dental follicles. |
| Keywords: | Immunohistochemistry Dental follicle Odontogenic epithelial PTCH |
| ISSN: | 0717-9502 |
| Is part of: | International Journal of Morphology |
| Language: | eng |
| Publisher / Institution : | Sociedad Chilena de Anatomía |
| Citation: | OLIVEIRA, D. M. et al. Immunohistochemical analysis of human homologue of drosophila patched (PTCH) in dental follicles of impacted third molars, International Journal of Morphology, Temuco, v. 30, n. 1, p. 105-109, 2012. Disponível em: https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100018&lng=en&nrm=iso&tlng=en. Acesso em: 29 set. 2025. |
| License: | Creative Commons Atribuição-NãoComercial 4.0 Internacional (CC BY-NC 4.0) |
| URI: | https://ri.ufs.br/jspui/handle/riufs/23314 |
| Appears in Collections: | DOD - Artigos de periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| ImmunohistochemicalAnalysisHumanHomologueDrosophila.pdf | 153,97 kB | Adobe PDF |  View/Open |
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