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https://ri.ufs.br/jspui/handle/riufs/23319| Document Type: | Artigo |
| Title: | Antinociceptive activity of thymoquinone and its structural analogues: a structure-activity relationship study |
| Authors: | Sousa, Damião Pergentino de Nobrega, Franklin Ferreira de Farias Santos, Camila Carolina de Menezes Benedito, Rubens Batista Vieira, Ygor Willian Uliana, Marciana Pierina Brocksom, Timothy John Almeida, Reinaldo Nobrega de |
| Issue Date: | Aug-2012 |
| Resumo : | Purpose: To investigate the structural features that influence the antinociceptive activity of thymoquinone and their structural analogues. Methods: The quinones were prepared by an oxidation procedure using molecular oxygen and catalysis with [CoII(salen)] from the respective phenols. The antinociceptive activity of para-benzoquinones (10 mg/kg, ip) was evaluated using formalin test in mice. Vehicle (5 % Tween 80) or morphine (10 mg/kg) were used as control group and standard drug, respectively. The amount of time spent licking the injected paw was considered as the nociceptive response. Results: Among the compounds tested, five para-benzoquinones showed antinociceptive activity. The 2-isopropyl-para-benzoquinone presented the highest potency in first and second phases and produced a near-maximal inhibition (p < 0.001) in the formalin test, similar to morphine (p < 0.001). Conclusion: Our experimental results show that by appropriate structural modification of parabenzoquinones it may be possible to develop novel analgesic drugs. |
| Keywords: | Quinones Antinociceptive activity Analgesic Central nervous system Structure-activity relationship Medicinal plant |
| ISSN: | 1596-9827 |
| Is part of: | Tropical journal of pharmaceutical research |
| Language: | eng |
| Publisher / Institution : | Pharmacotheraphy Group - University of Benin |
| Citation: | SOUSA, D. P. et al. Antinociceptive activity of thymoquinone and its structural analogues: a structure-activity relationship study, Tropical journal of pharmaceutical research, Benin City, v. 11, n. 4, p. 605-610, ago. 2012. Disponível em: https://www.ajol.info/index.php/tjpr/article/view/80570. Acesso em: 29 set. 2025. |
| License: | Creative Commons Atribuição 4.0 Internacional (CC BY 4.0) |
| URI: | https://ri.ufs.br/jspui/handle/riufs/23319 |
| Appears in Collections: | DFS - Artigos de periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| AntinociceptiveActivityThymoquinoneStructuralAnalogues.pdf | 352,3 kB | Adobe PDF |  View/Open |
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