Avaliação do perfil laboratorial e corporal associados à Doença Hepática Gordurosa Metabólica e Fibrose Hepática

Abstract

INTRODUCTION: Metabolic Fatty Liver Disease (MAFLD) is the most common liver disease worldwide, consisting of a complex series of elements in its pathogenesis that result in negative changes in the enzymatic variables that define liver function. OBJECTIVES To evaluate the most prevalent risk factors associated with Metabolic Fatty Liver Disease (MAFLD) and to assess the number of participants at high risk for liver fibrosis. METHODOLOGY: This is an observational, cross-sectional study conducted through a review of electronic medical records available on the management application for University Hospitals. The analysis focused on clinical data - age, weight, height, BMI, abdominal circumference, platelet count, and levels of aspartate aminotransferase and alanine aminotransferase - in individuals with risk factors such as overweight, obesity, metabolic dysregulation, and type 2 diabetes, for the development of MAFLD. RESULTS: A total of 677 medical records were analyzed, of which 256 (37.81%) were duplicates. This resulted in 421 (62.18%) patients, of whom 277 (40.91%) had risk factors for the development of DHGM, and 87(12,85%) were excluded from the study. Among the anthropometric parameters, significant differences were observed in weight and BMI. Regarding the laboratory parameters, levels of ALT, HDL, alkaline phosphatase, and gamma-GT showed notable results. CONCLUSION:This study highlighted that patients with obesity had a higher frequency of MAFLD, with obesity being the primary risk factor associated with MAFLD. Furthermore, 9.4% of patients with MAFLD were at high risk for advanced liver fibrosis, as indicated by the FIB-4 score.