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https://ri.ufs.br/jspui/handle/riufs/23588| Document Type: | Artigo |
| Title: | Borneol, a bicyclic monoterpene alcohol, reduces nociceptive behavior and inflammatory response in mice |
| Authors: | Almeida, Jackson Roberto Guedes da Silva Souza, Grasielly Rocha Silva, Juliane Cabral Saraiva, Sarah Raquel Gomes de Lima Oliveira Júnior, Raimundo Gonçalves de Quintans, Jullyana de Souza Siqueira Barreto, Rosana de Souza Siqueira Bonjardim, Leonardo Rigoldi Cavalcanti, Sócrates Cabral de Holanda Quintans Junior, Lucindo José |
| Issue Date: | 2013 |
| Resumo : | Borneol, a bicyclic monoterpene, has been evaluated for antinociceptive and anti-inflammatory activities. Antinociceptive and anti-inflammatory activities were studied by measuring nociception by acetic acid, formalin, hot plate, and grip strength tests, while inflammation was prompted by carrageenan-induced peritonitis. The rotarod test was used to evaluate motor coordination. Borneolproduced a significant (p < 0.01) reduction of the nociceptive behavior at the early and late phases of paw licking and reducedthe writhing reflex in mice (formalin and writhing tests, resp.). When the hot plate test was conducted, borneol (in higher dose)produced an inhibition (p < 0.05) of the nociceptive behavior. Such results were unlikely to be provoked by motor abnormality. Additionally, borneol-treated mice reduced the carrageenan-induced leukocytes migration to the peritoneal cavity. Together, ourresults suggest that borneol possess significant central and peripheral antinociceptive activity; it has also anti-inflammatory activity.In addition, borneol did not impair motor coordination. |
| Keywords: | Borneol Bicyclic monoterpene Antinociceptive and anti-inflammatory activities |
| ISSN: | 1537-744X |
| Is part of: | The Scientific World Journal |
| Language: | eng |
| Publisher / Institution : | Hindawi Publishing Corporation |
| Citation: | ALMEIDA, J. R. G. S. et al. Borneol, a bicyclic monoterpene alcohol, reduces nociceptive behavior and inflammatory response in mice. The Scientific World Journal, New York, n. 1, 2013. Disponível em: https://onlinelibrary.wiley.com/doi/epdf/10.1155/2013/808460. Acesso em: 21 out. 2025. |
| License: | Creative Commons Atribuição 3.0 Não Adaptada (CC BY 3.0) |
| URI: | https://ri.ufs.br/jspui/handle/riufs/23588 |
| Appears in Collections: | DFA - Artigos de periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| BorneolBicyclicMonoterpeneAlcohol.pdf | 358,4 kB | Adobe PDF |  View/Open |
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