Medidas dentárias mésio-distais em adultos com deficiência isolada do hormônio do crescimento

Abstract

Dental dimensions studies are rare in patients with isolated deficiency of growth hormone (IGHD). In Itabaianinha County, Sergipe, Brazil, has a large group of individuals with severe low stature caused by a homozygous mutation in releasing hormone receptor gene of growth hormone. The aim of this study was to evaluate the mesiodistal dental measures in adults with isolated deficiency of growth hormone. We evaluated 28 dental casts (upper and lower) of 14 adult patients with isolated deficiency of growth hormone (31.9 ± 9.9 years). Of these, nine men (29.8 ± 8.0 years) and five women (35.6 ± 12.8 years). The measurements were made using a specific software after scanning via a three-dimensional scanner. Measurements are expressed in absolute values and standard deviation score (SDS). All absolute values and SDS of patients with IGHD are statistically lower (P> 0.05) compared with the control group. Comparison of SDS values between the two genders demonstrated the absence of sexual dimorphism in MD measures in IGHD. SDS results after grouping genres allow us to observe that the SDS average was below than the normal value (-1.0 SDS) in all teeth except the central incisor (-0.42). Teeth exceeded the threshold of -2.0 SDS were the upper second molar (-2.42), upper canine (-2.87), upper central incisor (-3.09) and the lower first premolar (-2.27). Absolute values and SDS of mesial-distal width the teeth of IGHD patients are reduced, and lack of sexual dimorphism. The decrease in mesial-distal measures may be a more characteristic feature of congenital IGHD, severe and untreated demonstrating greater performance of GH on bone growth than tooth.