Influência do estímulo inflamatório na carcinogênese oral: estudo experimental histomorfológico

Abstract

Introduction: Inflammation is a natural response of the body against infection or tissue injury, in order to repair such damage. It has been suggested that inflammatory stimuli influence the growth and development of tumor lesions. Objective: To evaluate the consequences of the inflammatory stimulus in oral carcinogenesis. Material and Methods: an experimental study was conducted in Wistar rats with control groups (G0, G1A and G1B) and testing (G2A and G2B), where G1A and G2A groups were induced for 15 weeks and G1B and G2B groups for 33 weeks, both with 4NQO, and the test groups, in addition to induction, received an inflammatory stimulus during carcinogenesis. Differences between type of clinical lesions, degree of epithelial dysplasia and cell invasion were evaluated. Result: There was a statistically significant difference (p <0.05) for the mean score of epithelial dysplasia among G1B groups (50.8) and G2B (41.8). The invasion was present in 100% of cases induced for 33 weeks as well as the inflammatory infiltrate. Conclusion: The inflammatory stimulus did not change the level of dysplasia, however can have an effect on the degree of invasion and intensity / quality of the inflammatory infiltrate.