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Document Type:	Artigo
Title:	Distinct morphological features of NADPH diaphorase neurons across rodent's primary cortices
Authors:	Freire, Marco Aurelio de Moura Santos, José Ronaldo dos
Issue Date:	Apr-2013
Resumo :	Nitric oxide (NO) is a versatile gaseous molecule involved in several pathological and physiological functions in nervous system (Calabrese et al., 2007; Steinert et al., 2010; Freire, 2012). Its biosynthesis occurs after the stoichiometric conversion of L-arginine to L-citrulline in a process requiring the presence of NADPH and O2 as co-substrates (Bredt and Snyder, 1994). A group of enzymes known as nitric oxide synthases (NOS) is responsible to synthesize NO (Stuehr et al., 2004). In the brain, neuronal NOS is strictly co-localized with NADPH diaphorase (NADPH-d), an oxidative enzyme present in a discrete population of interneurons (Dawson et al., 1991). NADPH-d histochemistry has been used to reveal the presence of NO dispersed in neuropil and to evaluate the presence and distribution of NO-synthesizing neurons across several species.
Keywords:	Nitric oxide NADPH Morphological features Diaphorase neurons
ISSN:	1662-5110
Is part of:	Frontiers in Neural Circuits
Language:	eng
Publisher / Institution :	Frontiers Media S. A.
Citation:	FREIRE, M. A. M.; SANTOS, J. R. Distinct morphological features of NADPH diaphorase neurons across rodent's primary cortices. Frontiers in Neural Circuits, Lausanne, v. 7, n. 83, abr. 2013. Disponível em: https://www.frontiersin.org/journals/neural-circuits/articles/10.3389/fncir.2013.00083/full. Acesso em: 4 nov. 2025.
License:	Creative Commons Atribuição 3.0 Não Adaptada (CC BY 3.0)
URI:	https://ri.ufs.br/jspui/handle/riufs/23737
Appears in Collections:	DBI - Artigos de periódicos

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