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Tipo de Documento:	Artigo
Título :	Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in rats
Autor :	Leite, Camila Ferreira Marangoni, Fábio André Camargo, Enilton Aparecido Braga, Angélica de Fátima de Assunção Toro, Ivan Felizardo Contrera Antunes, Edson Landucci, Elen Cristina Tiezem Mussi, Ricardo Kalaf
Fecha de publicación :	2013
Resumen:	PURPOSE: To investigate the anti-inflammatory effects of simvastatin in rats undergoing one-lung ventilation (OLV) followed by lung re-expansion. METHODS: Male Wistar rats (n=30) were submitted to 1-h OLV followed by 1-h lung re-expansion. Treated group received simvastatin (40 mg/kg for 21 days) previous to OLV protocol. Control group received no treatment or surgical/ventilation interventions. Measurements of pulmonary myeloperoxidase (MPO) activity, pulmonary protein extravasation, and serum levels of cytokines and C-reactive protein (CRP) were performed. RESULTS: OLV significantly increased the MPO activity in the collapsed and continuously ventilated lungs (31% and 52% increase, respectively) compared with control (p<0.05). Treatment with simvastatin significantly reduced the MPO activity in the continuously ventilated lung but had no effect on lung edema after OLV. The serum IL-6 and CRP levels were markedly higher in OLV group, but simvastatin treatment failed to affect the production of these inflammatory markers. Serum levels of IL-1β, TNF-α and IL-10 remained below the detection limit in all groups. CONCLUSIONS: In an experimental one-lung ventilation model pre-operative treatment with simvastatin reduces remote neutrophil infiltration in the continuously ventilated lung. Our findings suggest that simvastatin may be of therapeutic value in OLV-induced pulmonary inflammation deserving clinical investigations.
Palabras clave :	Animals models Pulmonary ventilation Simvastatin Thoracic Surgery Inflammation Rats
ISSN :	1678-2674
Es parte de:	Acta Cirúrgica Brasileira
Idioma :	eng
Institución / Editorial :	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Citación :	LEITE, C. F. et al. Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in rats. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 4, p. 245-250, 2013. Disponível em: https://www.scielo.br/j/acb/a/tKKdFYDKb6kFRx7R3dHCVDK/?lang=en. Acesso em: 10 nov. 2025.
License:	Creative Commons Atribuição-NãoComercial 4.0 Internacional (CC BY-NC 4.0)
URI :	https://ri.ufs.br/jspui/handle/riufs/23816
Aparece en las colecciones:	DFS - Artigos de periódicos

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