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Tipo de Documento:	Artigo
Título :	The ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) reduces urinary bladder damage during cyclophosphamide-induced cystitis in rats
Autor :	Morais, Janaína Pereira Pereira, Denyson Santana Matos, Alexandre Santos Santana, Danielle Gomes Santos, Cliomar Alves dos Estevam, Charles dos Santos Fakhouri, Ricardo De Lucca Junior, Waldecy Camargo, Enilton Aparecido
Fecha de publicación :	2013
Resumen:	Hemorrhagic cystitis (HC) is a common side effect of cyclophosphamide therapy, which deserves new therapeutic strategies, such as those based on natural products. The ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) (EECp) possesses anti-inflammatory, antinociceptive, and antioxidant activities as previously showed by our group. We have investigated the effect of EECp on the cyclophosphamide-induced HC. Cystitis was induced in male Wistar rats by the injection of cyclophosphamide. These animals were pretreated with EECp (100–400 mg/kg), vehicle, or mesna. Myeloperoxidase activity and malondialdehyde formation were measured in urinary bladder and other tissues. Bladder edema and histopathological alterations and serum nitric oxide metabolites concentration mathematical equation were also evaluated. Treatment with EECp (100–400 mg/kg) or mesna impaired the increase of myeloperoxidase activity in urinary bladder and the serum mathematical equation induced by cyclophosphamide but did not reduce edema in this tissue, as did mesna. Total histological score was reduced by EECp (100 mg/kg). Lung myeloperoxidase activity, which was increased by cyclophosphamide, was decreased significantly by EECp (400 mg/kg). EECp also diminished the malondialdehyde formation in bladder, lung, and spleen, although these parameters were not affected by cyclophosphamide. These results indicate that EECp reduced urinary bladder damage during cyclophosphamide-induced HC in rats.
Palabras clave :	Hemorrhagic cystitis Cyclophosphamide therapy Ethanol extract Caesalpinia pyramidalis
ISSN :	1537-744X
Es parte de:	The Scientific World Journal
Idioma :	eng
Institución / Editorial :	Hindawi Publishing Corporation
Citación :	MORAIS, J. P. et al. The ethanol extract of the inner bark of Caesalpinia pyramidalis (Tul.) reduces urinary bladder damage during cyclophosphamide-induced cystitis in rats. The Scientific World Journal, New York, n. 1, 2013. Disponível em: https://onlinelibrary.wiley.com/doi/epdf/10.1155/2013/694010. Acesso em: 12 nov. 2025.
License:	Creative Commons Atribuição 3.0 Não Adaptada (CC BY 3.0)
URI :	https://ri.ufs.br/jspui/handle/riufs/23841
Aparece en las colecciones:	DFS - Artigos de periódicos

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