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Tipo de Documento:	Artigo
Título :	Metabolic, hemodynamic and structural adjustments to low intensity exercise training in a metabolic syndrome model
Autor :	Morvan, Eduardo Lima, Nathalia Edviges Alves Machi, Jacqueline Freire Mostarda, Cristiano De Angelis, Kátia Irigoyen, Maria Cláudia Wichi, Rogério Brandão Rodrigues, Bruno Maifrino, Laura Beatriz Mesiano
Fecha de publicación :	2013
Resumen:	Background: The increase in fructose consumption is paralleled by a higher incidence of metabolic syndrome, and consequently, cardiovascular disease mortality. We examined the effects of 8 weeks of low intensity exercise training (LET) on metabolic, hemodynamic, ventricular and vascular morphological changes induced by fructose drinking in male rats. Methods: Male Wistar rats were divided into (n = 8 each) control (C), sedentary fructose (F) and ET fructose (FT) groups. Fructose-drinking rats received D-fructose (100 g/l). FT rats were assigned to a treadmill training protocol at low intensity (30% of maximal running speed) during 1 h/day, 5 days/week for 8 weeks. Measurements of triglyceride concentrations, white adipose tissue (WAT) and glycemia were carried out together with insulin tolerance test to evaluate metabolic profile. Arterial pressure (AP) signals were directly recorded. Baroreflex sensitivity (BS) was evaluated by the tachycardic and bradycardic responses. Right atria, left ventricle (LV) and ascending aorta were prepared to morphoquantitative analysis. Results: LET reduced WAT (−37.7%), triglyceride levels (−33%), systolic AP (−6%), heart weight/body weight (−20.5%), LV (−36%) and aortic (−76%) collagen fibers, aortic intima-media thickness and circumferential wall tension in FT when compared to F rats. Additionally, FT group presented improve of BS, numerical density of atrial natriuretic peptide granules (+42%) and LV capillaries (+25%), as well as the number of elastic lamellae in aorta compared with F group. Conclusions: Our data suggest that LET, a widely recommended practice, seems to be particularly effective for preventing metabolic, hemodynamic and morphological disorders triggered by MS.
Palabras clave :	Fructose Exercise training Triglycerides Insulin resistance Baroreflex sensitivity Cardiovascular remodeling Aorta remodeling
ISSN :	1475-2840
Es parte de:	Cardiovascular Diabetology
Idioma :	eng
Institución / Editorial :	BioMed Central
Citación :	MORVAN, E. et al. Metabolic, hemodynamic and structural adjustments to low intensity exercise training in a metabolic syndrome model. Cardiovascular Diabetology, London, v. 12, n. 89, 2013. Disponível em: https://cardiab.biomedcentral.com/articles/10.1186/1475-2840-12-89. Acesso em: 12 nov. 2025.
License:	Creative Commons Atribuição 2.0 Genérica (CC BY 2.0)
URI :	https://ri.ufs.br/jspui/handle/riufs/23842
Aparece en las colecciones:	DEF - Artigos de periódicos

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