Comparison of two vasoconstrictors on glycemic levels in diabetic patients

Abstract

We evaluated glycemic levels in diabetic patients before, during, and after exodontia using 2% lidocaine with 1:100,000 epinephrine (Lido/Epi) and 3% prilocaine with 0.03 IU/mL felypressin (Prilo/Fely). A double-blind, randomized clinical study was conducted to evaluate changes in body parameters and glycemic levels in diabetic patients undergoing two anesthetic protocols during dental extractions. During surgery, we evaluated hemodynamic parameters such as blood pressure (BP), heart rate (HR), saturation (SpO2), and capillary glycemic levels (Gly), which were measured at different surgical moments: basal, 30 min after medication, incision, alveolus removal, suture, and 30 and 60 min after anesthesia. The data analysis showed no statistically significant differences (t test) between the groups inage, weight, and time of surgery. In the Lido/Epi group, increased systolic BP and decreased diastolic BP were observed. No significant difference was observed in the Prilo/Fely group among the surgical moments or between the groups regarding BP. No significant difference was observed in HR, SpO2, and Gly between the groups at any surgical moment (P> 0.05). In anxiety level evaluation, there was no difference between the different surgical moments. Thus, both Lido/Epi and Prilo/Fely (maximum 3.6 mL) can be safely used in controlled diabetic patients.