Dimensão dentária mésio distal de adultos com deficiência isolada do hormônio do crescimento tratados com reposição hormonal

Abstract

In Itabaianinha-SE, a large family was identified as presenting an inactivating mutation of the growth hormone releasing hormone receptor gene. This mutation causes a severe and proportionate short stature in which the individual finds two standard deviations below the population mean. During the adolescent phase, the research group performed a replacement therapy with growth hormone (GH), resulting in increased stature, but little is known about the effects on the dental dimensions. This research, the precursor, aims to evaluate the mesio distal dental measurements of patients with isolated and genetic deficiency of growth hormone (GHD) who underwent GH treatment. Seven patients (5 men and 2 women) were molded, the models were obtained, scanned and then the teeth were measured digitally with specific software. The data were analyzed statistically and compared to the group with DIGH that did not use GH. The result showed that all dental measures of the treated DIGH group were similar to the untreated DIGH group. In conclusion, the use of GH in childhood and adolescence does not seem to modify the distal mesio dimensions because the odontogenesis process has already been completed or is in its final phase.