Use este identificador para citar ou linkar para este item:
https://ri.ufs.br/jspui/handle/riufs/24156| Tipo de Documento: | Artigo |
| Título: | Nanostructured transdermal hormone replacement therapy for relieving menopausal symptoms: a confocal Raman spectroscopy study |
| Autor(es): | Botelho, Marco Antonio Queiroz, Dinalva Brito Barros, Gisele Guerreiro, Stela Fechine, Pierre Umbelino, Sônia Lyra, Arão Borges, Boniek Freitas, Allan Queiroz, Danilo Caldas de Ruela, Ronaldo Almeida, Jackson Guedes Quintans Júnior, Lucindo José |
| Data do documento: | 2014 |
| Resumo: | OBJECTIVE: To determine the safety and efficacy of a transdermal nanostructured formulation of progesterone (10%) combined with estriol (0.1%) + estradiol (0.25%) for relieving postmenopausal symptoms. METHODS: A total of 66 postmenopausal Brazilian women with climacteric symptoms of natural menopause received transdermal nanostructured formulations of progesterone and estrogens in the forearm daily for 60 months to mimic the normal ovarian secretory pattern. Confocal Raman spectroscopy of hormones in skin layers was performed. Clinical parameters, serum concentrations of estradiol and follicle-stimulating hormone, blood pressure, BI-RADS classification from bilateral mammography, and symptomatic relief were compared between baseline and 60 months post-treatment. Clinicaltrials.gov: NCT02033512. RESULTS: An improvement in climacteric symptoms was reported in 92.5% of women evaluated before and after 60 months of treatment. The serum concentrations of estradiol and follicle-stimulating hormone changed significantly (p,0.05) after treatment; the values of serum follicle-stimulating hormone decreased after 60 months from 82.04¡4.9 to 57.12¡4.1 IU/mL. A bilateral mammography assessment of the breasts revealed normal results in all women. No adverse health-related events were attributed to this hormone replacement therapy protocol. CONCLUSION: The nanostructured formulation is safe and effective in re-establishing optimal serum levels of estradiol and follicle-stimulating hormone and relieving the symptoms of menopause. This transdermal hormone replacement therapy may alleviate climacteric symptoms in postmenopausal women. |
| Palavras-chave: | Nanotechnology Confocal Raman spectroscopy Transdermal delivery Menopause Hormone therapy Nanoparticles |
| ISSN: | 1980-5322 |
| Parte de : | Clinics |
| Idioma: | eng |
| Instituição/Editora: | Faculdade de Medicina da Universidade de São Paulo |
| Citação: | BOTELHO, M. A. et al. Nanostructured transdermal hormone replacement therapy for relieving menopausal symptoms: a confocal Raman spectroscopy study. Clinics, São Paulo, v. 69, n. 2, p. 75-82, 2014. Disponível em: https://www.scielo.br/j/clin/a/xtwXWHWXjDVX4sZKVgVSyTM/abstract/?lang=en. Acesso em: 8 jan. 2026. |
| Licença: | Creative Commons Atribuição 4.0 Internacional (CC BY 4.0) |
| URI: | https://ri.ufs.br/jspui/handle/riufs/24156 |
| Aparece nas coleções: | DFS - Artigos de periódicos |
Arquivos associados a este item:
| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| NanostructuredTransdermalHormoneReplacementTherapy.pdf | 2,83 MB | Adobe PDF |  Visualizar/Abrir |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.