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https://ri.ufs.br/jspui/handle/riufs/24435| Document Type: | Artigo |
| Title: | Electroacupuncture reduces hyperalgesia after injections of acidic saline in rats |
| Authors: | Maciel, Leonardo Yung dos Santos Cruz, Kamilla Mayara Lucas da Araujo, Ariane Martins de Silva, Zak Moreira de Andrade Badauê Passos, Daniel Santana-Filho, Valter Joviniano DeSantana, Josimari Melo |
| Issue Date: | 2014 |
| Resumo : | Injections of acidic saline into the gastrocnemius muscle in rats produce a bilateral long-lasting hyperalgesia similarto fibromyalgia in humans. No previous study investigated the effect of electroacupuncture (EA) on this acidic saline model. Thisstudy aimed to identify the effects of EA in the hyperalgesia produced by repeated intramuscular injections of acidic saline. Methods.Rats were divided into four groups (n = 6, each group): control, acupuncture, EA 15 Hz, and 100 Hz. Left gastrocnemius musclewas injected with 100 uL of pH 4.0 sterile saline twice five days apart. EA, acupuncture, or control therapy was daily administered(20 min) for 5 consecutive days under anesthesia. Needles were placed in the St36 and Sp6 acupoints. The assessment of secondarymechanical hyperalgesia, thermal hyperalgesia, and motor performance was performed before injections and before and after thetreatment performed on each day. The paw withdrawal threshold was tested using the nonparametric Kruskal-Wallis test anddifferences within the group Wilcoxon Matched Pairs. The latency and motor performance were tested for ANOVA parametrictest for independent measures, and for differences in the group, we used t-test for paired samples. Post hoc Tukey test was used formultiple corrections. p values less than 0.05 were considered statistically significant. Results. Indicate that there was a significantreduction of mechanical withdrawal threshold and paw withdrawal latency 24 hours following the second injection. Moreover,mechanical and thermal hyperalgesia were significantly reversed by EA 15, 100 Hz, and acupuncture. Conclusions. The results suggestthat EA high and low frequency as well as acupuncture are effective in reducing hyperalgesia in chronic muscle pain model. |
| Keywords: | Gastrocnemius muscle Electroacupuncture Hyperalgesia Acidic saline model |
| ISSN: | 1741-4288 |
| Is part of: | Evidence-Based Complementary and Alternative Medicine |
| Language: | eng |
| Publisher / Institution : | Hindawi Publishing Corporation |
| Citation: | MACIEL, L. Y. S. et al. Electroacupuncture reduces hyperalgesia after injections of acidic saline in rats. Evidence-Based Complementary and Alternative Medicine, New York, n. 1, 2014. Disponível em: https://onlinelibrary.wiley.com/doi/10.1155/2014/485043. Acesso em: 28 jan. 2026. |
| License: | Creative Commons Atribuição 3.0 Não Adaptada (CC BY 3.0) |
| Identifier: | https://doi.org/10.1155/2014/485043 |
| URI: | https://ri.ufs.br/jspui/handle/riufs/24435 |
| Appears in Collections: | DFS - Artigos de periódicos DFT - Artigos de periódicos PPGCS - Artigos de periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| EletroacupunctureHyperalgesiaAcidicSaline.pdf | 705,98 kB | Adobe PDF |  View/Open |
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