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https://ri.ufs.br/jspui/handle/riufs/24757| Document Type: | Artigo |
| Title: | Redox-active profile characterization of Remirea maritima extracts and its cytotoxic effect in mouse fibroblasts (L929) and melanoma (B16f10) cells |
| Authors: | Dória, Grace Anne Azevedo Santos, Anderson Ribeiro dos Bittencourt, Leonardo S. Bortolin, Rafael Calixto Menezes, Paula dos Passos Vasconcelos, Bruno S. Souza, Rebeca O. Fonseca, Maria José Vieira Santos, Alan Diego da Conceição Saravana, Shanmugam Silva, Francilene Amaral da Gelain, Daniel Pens Moreira, José Claudio Fonseca Prata, Ana Paula do Nascimento Quintans Júnior, Lucindo José Araújo, Adriano Antunes de Souza |
| Issue Date: | 2015 |
| Resumo : | Remirea maritima is a tropical plant with a reticulated root system belonging to the family Cyperaceae, also known to have biologically active secondary metabolites. However, very few data on R. maritima’s biological actions are available and there are no reports regarding the redox-active profile of this plant. In this study, we examined the total phenolic content of Remirea maritima hydroalcoholic (RMHA) extracts, redox properties against different reactive species generated in vitro and their cytotoxic effect against fibroblasts (L929) and melanoma (B16F10) cells. Total reactive antioxidant potential index (TRAP) and total antioxidant reactivity (TAR) results revealed that RMHA at all concentrations tested showed significant antioxidant capacity. RMHA was also effective against hydroxyl radical formation, reduction of Fe3+ to Fe2+ and in scavenging nitric oxide (NO) radicals. In vitro, the level of lipid peroxidation was reduced by RMHA extract and the data showed significant oxidative damage protection. The RMHA cytotoxicity was evaluated by a neutral red assay in fibroblast (L929) and melanome (B16F10) cells. The obtained results showed that the RMHA (40 and 80 µg/mL, respectively) reduced 70% of the viable cells. In conclusion, this study represents the first report regarding the antioxidant and anti-proliferative potential of R. maritima against B16F10 melanoma cells. |
| Keywords: | Remirea maritima Free radicals Cellular viability Oxidative stress Cytotoxicity Total phenol |
| ISSN: | 1420-3049 |
| Is part of: | Molecules |
| Language: | eng |
| Publisher / Institution : | MDPI |
| Citation: | DÓRIA, G. A. A. et al. Redox-active profile characterization of Remirea maritima extracts and its cytotoxic effect in mouse fibroblasts (L929) and melanoma (B16f10) cells. Molecules, Basel, v. 20, n. 7, p. 11669–11718, 2015. Disponível em: https://www.mdpi.com/1420-3049/20/7/11699. Acesso em: 12 mar. 2026. |
| License: | Creative Commons Atribuição 4.0 Internacional (CC BY 4.0) |
| Identifier: | https://doi.org/10.3390/molecules200711699 |
| URI: | https://ri.ufs.br/jspui/handle/riufs/24757 |
| Appears in Collections: | DBI - Artigos de periódicos DFA - Artigos de periódicos DFS - Artigos de periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| RedoxActiveProfileRemireaMaritima.pdf | 922,39 kB | Adobe PDF |  View/Open |
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