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Tipo de Documento:	Artigo
Título :	Distribution and morphology of calcium-binding proteins immunoreactive neurons following chronic tungsten multielectrode implants
Autor :	Freire, Marco Aurelio de Moura Faber, Jean Lemos, Nelson Alessandretti de Mello Santos, José Ronaldo Cavalcanti, Pedro França Lima, Ramon Hypolito Morya, Edgard
Fecha de publicación :	2015
Resumen:	The development of therapeutic approaches to improve the life quality of people suffering from different types of body paralysis is a current major medical challenge. Brain-machine interface (BMI) can potentially help reestablishing lost sensory and motor functions, allowing patients to use their own brain activity to restore sensorimotor control of paralyzed body parts. Chronic implants of multielectrodes, employed to record neural activity directly from the brain parenchyma, constitute the fundamental component of a BMI. However, before this technique may be effectively available to human clinical trials, it is essential to characterize its long-term impact on the nervous tissue in animal models. In the present study we evaluated how chronic implanted tungsten microelectrode arrays impact the distribution and morphology of interneurons reactive to calcium-binding proteins calbindin (CB), calretinin (CR) and parvalbumin (PV) across the rat’s motor cortex. Our results revealed that chronic microelectrode arrays were well tolerated by the nervous tissue, with recordings remaining viable for up to 6 months after implantation. Furthermore, neither the morphology nor the distribution of inhibitory neurons were broadly impacted. Moreover, restricted microglial activation was observed on the implanted sites. On the whole, our results confirm and expand the notion that tungsten multielectrodes can be deemed as a feasible candidate to future human BMI studies.
Palabras clave :	Body paralysis Brain-machine interface Therapeutic approaches Tungsten multielectrode implants
ISSN :	1932-6203
Es parte de:	PloS One
Idioma :	eng
Institución / Editorial :	Public Library of Science
Citación :	FREIRE, M. A. M. et al. Distribution and morphology of calcium-binding proteins immunoreactive neurons following chronic tungsten multielectrode implants. PLoS ONE, San Francisco, v. 10, n. 6, 2015. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130354. Acesso em: 6 abr. 2026.
License:	Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)
Identificador:	https://doi.org/10.1371/journal.pone.01303
URI :	https://ri.ufs.br/jspui/handle/riufs/25071
Aparece en las colecciones:	DBCI - Artigos de periódicos

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