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Document Type:	Artigo
Title:	Comparative anticonvulsant study of epoxycarvone stereoisomers
Authors:	Salgado, Paula Regina Rodrigues Fonsêca, Diogo Vilar da Braga, Renan Marinho Melo, Cynthia Germoglio Farias de Andrade, Luciana Nalone Almeida, Reinaldo Nóbrega de Sousa, Damião Pergentino de
Issue Date:	2015
Resumo :	Stereoisomers of the monoterpene epoxycarvone (EC), namely (+)-cis-EC, (´)-cis-EC, (+)-trans-EC, and (´)-trans-EC, were comparatively evaluated for anticonvulsant activity in specific methodologies. In the pentylenetetrazole (PTZ)-induced anticonvulsant test, all of the stereoisomers (at 300 mg/kg) increased the latency to seizure onset, and afforded 100% protection against the death of the animals. In the maximal electroshock-induced seizures (MES) test, prevention of tonic seizures was also verified for all of the isomers tested. However, the isomeric forms (+) and (´)-trans-EC showed 25% and 12.5% inhibition of convulsions, respectively. In the pilocarpine-induced seizures test, all stereoisomers demonstrated an anticonvulsant profile, yet the stereoisomers (+) and (´)-trans-EC (at 300 mg/kg) showed a more pronounced effect. A strychnine-induced anticonvulsant test was performed, and none of the stereoisomers significantly increased the latency to onset of convulsions; the stereoisomers probably do not act in this pathway. However, the stereoisomers (+)-cis-EC and (+)-trans-EC greatly increased the latency to death of the animals, thus presenting some protection. The four EC stereoisomers show promise for anticonvulsant activity, an effect emphasized in the isomers (+)-cis-EC, (+)-trans-EC, and (´)-trans-EC for certain parameters of the tested methodologies. These results serve as support for further research and development of antiepileptic drugs from monoterpenes.
Keywords:	Anticonvulsant Carvone Stereoisomers Terpene Natural products Essential oils Pentylenetetrazole Seizures Para-menthanes Enantiomers
ISSN:	1420-3049
Is part of:	Molecules
Language:	eng
Publisher / Institution :	MDPI
Citation:	SALGADO, P. R. R. et al. Comparative anticonvulsant study of epoxycarvone stereoisomers. Molecules, Basel, v. 20, n. 11, p. 19660-19673, 2015. Disponível em: https://www.mdpi.com/1420-3049/20/11/19649. Acesso em: 29 abr. 2026.
License:	Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)
Identifier:	https://doi.org/10.3390/molecules201119649
URI:	https://ri.ufs.br/jspui/handle/riufs/25120
Appears in Collections:	DFA - Artigos de periódicos

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