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Document Type:	Artigo
Title:	Antinociceptive and anti-inflammatory activities of the ethanolic extract of Annona vepretorum Mart. (Annonaceae) in rodents
Authors:	Silva, Juliane Cabral Araújo, Camila de Souza Lima-Saraiva, Sarah Raquel Gomes de Oliveira Júnior, Raimundo Gonçalves de Diniz, Tâmara Coimbra Wanderley, Carlos Wagner de Souza Palheta Júnior, Raimundo Campos Mendes, Rosemairy Luciane Guimarães, Adriana Gibara Quintans Júnior, Lucindo José Almeida, Jackson Roberto Guedes da Silva
Issue Date:	2015
Resumo :	Background: Annona vepretorum Mart. (Annonaceae) is a native tree from Caatinga (Brazilian Northeastern savanna biome), popularly known as “araticum” and “pinha da Caatinga”. In this study, we investigated the effects of the crude ethanolic extract (Av-EtOH) in models of pain and inflammation in rodents. Methods: The evaluation of antinociceptive activity was carried out by the acetic acid-induced writhing, formalin, hot plate and tail flick tests, while paw edema induced by carrageenan or histamine, and leukocyte migration to the peritoneal cavity were used for anti-inflammatory profile. Histological analyses also were carried out. Results: Av-EtOH (25, 50 and 100 mg/kg, p.o) significantly reduced the number of writhing (P < 0.01) and decreased (P < 0.01) the paw licking time in both phases of the formalin test. In the hot plate and tail flick tests, this extract increased the reaction time, consequently reduced painful behavior. The effects in the formalin and hot plate tests were antagonized by naloxone. Av-EtOH inhibited significantly (P < 0.01) the increase in the edema volume after administration of carrageenan and histamine. In the peritonitis test, acute pre-treatment with Av-EtOH inhibited leukocyte migration. Histological analysis showed less inflammation in the groups treated with the extract when the inflammation was induced by carrageenan or histamine. Conclusion: Thus, Av-EtOH has significant antinociceptive and anti-inflammatory properties, which are related probably with the activation of opioid receptors and inhibition of release of mediators of the inflammatory process. This specie is a potential target for drug discovery.
Keywords:	Pain Inflammation Annona vepretorum
ISSN:	2662-7671
Is part of:	BMC Complementary and Alternative Medicine
Language:	eng
Publisher / Institution :	BioMed Central
Citation:	SILVA, J. C. et al. Antinociceptive and anti-inflammatory activities of the ethanolic extract of Annona vepretorum Mart. (Annonaceae) in rodents. BMC Complementary and Alternative Medicine, London, v. 15, n. 197, 2015. Disponível em: https://link.springer.com/article/10.1186/s12906-015-0716-2. Acesso em: 8 maio 2026.
License:	Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)
Identifier:	https://doi.org/10.1186/s12906-015-0716-2
URI:	https://ri.ufs.br/jspui/handle/riufs/25142
Appears in Collections:	DFS - Artigos de periódicos

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