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Document Type:	Artigo
Title:	The vasorelaxant effect of p-Cymene in rat aorta involves potassium channels
Authors:	Silva, Martapolyana Torres Menezes da Ribeiro, Fernanda Pires Rodrigues de Almeida Medeiros, Maria Alice Miranda Bezerra Sampaio, Pedrita Alves Silva, Yonara M. S. Silva, Morganna Thinesca Almeida Quintans, Jullyana de Souza Siqueira Quintans Júnior, Lucindo José Ribeiro, Luciano Augusto de Araújo
Issue Date:	2015
Resumo :	The monoterpenes are the main constituents of most essential oils and p-cymene is a monoterpene commonly found in various species of aromatic herbs, which has been reported for anti-inflammatory, antinociceptive, and antimicrobial activities. However,there is no report concerning its pharmacological activity on the vascular smooth muscle. The aim of current work was to investigatethe effects of p-cymene in isolated rat aorta and also study its mechanism of action. In this work, we show that p-cymene has arelaxant effect, in a dose-dependent way, on the vascular smooth muscle, regardless of the presence of the endothelium. Using anonselective potassium channel blocker, the CsCl, the relaxant effect of p-cymene was attenuated. In the presence of more selectivepotassium channels blockers, such as TEA or 4-AP, no change in the relaxant effect of p-cymene was evidenced, indicating thatBKCa and K V channels are not involved in that relaxant effect. However, in the presence of glibenclamide or BaCl2, KATP and K irblockers, respectively, the relaxant effect of p-cymene was attenuated. The data presented indicate that p-cymene has a relaxingeffect on rat aorta, regardless of the endothelium, but with the participation of the KATP and Kir channels.
Keywords:	Monoterpenes P-cymene Antinociceptive and anti-inflammatory activities
ISSN:	1537-744X
Is part of:	The Scientific World Journal
Language:	eng
Publisher / Institution :	Hindawi Publishing Corporation
Citation:	SILVA, M. T. M. et al. The vasorelaxant effect of p-Cymene in rat aorta involves potassium channels. The Scientific World Journal, New York, n. 1, 2015. Disponível em: https://onlinelibrary.wiley.com/doi/10.1155/2015/458080. Acesso em: 8 maio 2026.
License:	Creative Commons Atribuição 3.0 Não Adaptada (CC BY 3.0)
Identifier:	https://doi.org/10.1155%2F2015%2F458080
URI:	https://ri.ufs.br/jspui/handle/riufs/25143
Appears in Collections:	DFS - Artigos de periódicos

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