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Document Type:	Artigo
Title:	In vivo anti-tumor activity and toxicological evaluations of perillaldehyde 8,9-epoxide, a derivative of perillyl alcohol
Authors:	Andrade, Luciana Nalone Amaral, Ricardo Guimarães Dória, Grace Anne Azevedo Fonseca, Cecília Santos Silva, Tayane Kayane Mariano da Albuquerque Júnior, Ricardo Luiz Cavalcante Thomazzi, Sara Maria Nascimento, Lázaro Gomes do Carvalho, Adriana Andrade Sousa, Damião Pergentino de
Issue Date:	2016
Resumo :	Recent studies have revealed the high cytotoxicity of p-menthane derivatives against human tumor cells. In this study, the substance perillaldehyde 8,9-epoxide, a p-menthane class derivative obtained from (S)-(´)-perillyl alcohol, was selected in order to assess antitumor activity against experimental sarcoma 180 tumors. Toxicological effects related to the liver, spleen, kidneys and hematology were evaluated in mice submitted to treatment. The tumor growth inhibition rate was 38.4%, 58.7%, 35.3%, 45.4% and 68.1% at doses of 100 and 200 mg/kg/day for perillaldehyde 8,9-epoxide, perillyl alcohol and 25 mg/kg/day for 5-FU intraperitoneal treatments, respectively. No toxicologically significant effect was found in liver and kidney parameters analyzed in Sarcoma 180-inoculated mice treated with perillaldehyde 8,9-epoxide. Histopathological analyses of the liver, spleen, and kidneys were free from any morphological changes in the organs of the animals treated with perillaldehyde 8,9-epoxide. In conclusion, the data suggest that perillaldehyde 8,9-epoxide possesses significant antitumor activity without systemic toxicity for the tested parameters. By comparison, there was no statistical difference for the antitumor activity between perillaldehyde 8,9-epoxide and perillyl alcohol.
Keywords:	P-menthanes Monoterpenes Essential oils Natural products Antitumor activity Sarcoma 180 Toxicity Anticancer Perillyl alcohol
ISSN:	1422-0067
Is part of:	International Journal of Molecular Sciences
Language:	eng
Publisher / Institution :	MDPI Center
Citation:	ANDRADE, L. N. et al. In vivo anti-tumor activity and toxicological evaluations of perillaldehyde 8,9-epoxide, a derivative of perillyl alcohol. International Journal of Molecular Sciences, Basel, v. 17, n. 1, 2016. Disponível em: https://www.mdpi.com/1422-0067/17/1/32. Acesso em: 21 maio 2026.
License:	Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)
Identifier:	https://doi.org/10.3390/ijms17010032
URI:	https://ri.ufs.br/jspui/handle/riufs/25165
Appears in Collections:	DFS - Artigos de periódicos

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