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Document Type:	Artigo
Title:	Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil
Authors:	Matos, Diana Melo de Ramalho, Roberto J. R. Carvalho, Bruno M. Almeida, Maria Augusta C. T. Passos, Luciana F. D. Vasconcelos, Talmay Tavares Santos Melo, Enaldo Vieira de Oliveira, Carla Raquel Pereira Santos, Elenilde Gomes Rezende, Karla Freire Oliveira, Manuel Hermínio de Aguiar
Issue Date:	2016
Resumo :	Objectives: To assess the evolution to permanent or transient conditions in children with positive neonatal TSH tests in Sergipe, Brazil, from 2004 to 2010. Subjects and methods: Out of 193,794 screened newborns, 713 presented a neonatal TSH level higher than the local cutoff (5.2 µU/mL). From the confirmatory serum TSH values, the children were diagnosed with initial congenital hypothyroidism (CH) or suspect CH. From the evolution, they were classified as permanent CH, hyperthyrotropinemia, or transient TSH elevation. The mean incidence of each final condition was calculated for the total period of time. Results: The initial diagnosis included 37 CH (18.1%) and 167 suspect CH (81.9%) cases. The final diagnosis included 46 cases of permanent CH (22.5%), 56 of hyperthyrotropinemia (27.5%), and 102 of transient TSH elevation (50.0%). Out of the 37 cases of initial CH, 23 (62.2%) had permanent CH, nine (24.3%) had hyperthyrotropinemia, and five (13.5%) had transient TSH elevation. Out of the 167 suspect CH cases, 23 (13.8%) had permanent CH, 47 (28.1%) had hyperthyrotropinemia and 97 (58.1%) had transient TSH elevation. The mean incidence after the follow up was 1:4,166 for permanent CH, 1:3,448 for hyperthyrotropinemia, and 1:1,887 for transient TSH elevation. Eighty-six percent of the children with an initial diagnosis of CH and 41.9% with suspect CH had a permanent condition (CH or hyperthyrotropinemia). Conclusions: The follow-up of children with an initial diagnosis of CH or suspect CH is necessary to determine whether the disorder is permanent because predicting the evolution of the condition is difficult.
Keywords:	Neonatal screening Congenital hypothyroidism Thyrotropin Thyroid hormones
ISSN:	2359-4292
Is part of:	Archives of Endocrinology and Metabolism
Language:	eng
Publisher / Institution :	Sociedade Brasileira de Endocrinologia e Metabologia
Citation:	MATOS, D. M. et al. Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil. Archives of Endocrinology and Metabolism, São Paulo, v. 60, n. 5, p. 450–456, 2016. Disponível em: https://www.scielo.br/j/aem/a/CJHhtpD7RrZ5wBPfSRqRXLd/?lang=en. Acesso em: 14 jul. 2026.
License:	Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)
Identifier:	https://doi.org/10.1590/2359-3997000000189
URI:	https://ri.ufs.br/jspui/handle/riufs/25538
Appears in Collections:	DME - Artigos de periódicos HU - Artigos de periódicos

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