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Tipo de Documento:	Artigo
Título :	Essential oil of Ocimum basilicum L. and (−)-Linalool blocks the excitability of rat sciatic nerve
Autor :	Venancio, Antonio Medeiros Ferreira da Silva, Francisco Walber Silva-Alves, Kerly Shamyra da Pimentel, Hugo de Carvalho Lima, Matheus Macêdo Santana, Michele Fraga de Alves, Péricles Barreto Silva, Givanildo Batista da Leal-Cardoso, José Henrique Marchioro, Murilo
Fecha de publicación :	2016
Resumen:	The racemate linalool and its levogyrus enantiomer [(−)-LIN] are present in many essential oils and possess several pharmacological activities, such as antinociceptive and anti-inflammatory. In this work, the effects of essential oil obtained from the cultivation of the Ocimum basilicum L. (EOOb) derived from Germplasm Bank rich in (−)-LIN content in the excitability of peripheral nervous system were studied. We used rat sciatic nerve to investigate the EOOb and (−)-LIN effects on neuron excitability and the extracellular recording technique was used to register the compound action potential (CAP). EOOb and (−)-LIN blocked the CAP in a concentration-dependent way and these effects were reversible after washout. EOOb blocked positive amplitude of 1st and 2nd CAP components with IC50 of 0.38 ± 0.2 and 0.17 ± 0.0 mg/mL, respectively. For (−)-LIN, these values were 0.23 ± 0.0 and 0.13 ± 0.0 mg/mL. Both components reduced the conduction velocity of CAP and the 2nd component seems to be more affected than the 1st component. In conclusion EOOb and (−)-LIN inhibited the excitability of peripheral nervous system in a similar way and potency, revealing that the effects of EOOb on excitability are due to the presence of (−)-LIN in the essential oil.
Palabras clave :	Linalool Essential oils Rat sciatic nerve Peripheral nervous system Excitability
ISSN :	1741-4288
Es parte de:	Evidence-Based Complementary and Alternative Medicine
Idioma :	eng
Institución / Editorial :	Hindawi Publishing Corporation
Citación :	VENANCIO, A. M. et al. Essential oil of Ocimum basilicum L. and (−)-Linalool blocks the excitability of rat sciatic nerve. Evidence-Based Complementary and Alternative Medicine, New York, n. 1, 2016. Disponível em: https://onlinelibrary.wiley.com/doi/10.1155/2016/9012605. Acesso em: 14 jul. 2026.
License:	Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)
Identificador:	https://doi.org/10.1155/2016/9012605
URI :	https://ri.ufs.br/jspui/handle/riufs/25546
Aparece en las colecciones:	DFS - Artigos de periódicos DQI - Artigos de periódicos

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