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https://ri.ufs.br/jspui/handle/riufs/25834| Document Type: | Artigo |
| Title: | Menadione (vitamin K) enhances the antibiotic activity of drugs by cell membrane permeabilization mechanism |
| Authors: | Andrade, Jacqueline Cosmo Braga, Maria Flaviana Bezerra Morais Guedes, Glaucia Morgana de Melo Tintino, Saulo Relison Freitas, Maria Audilene de Quintans Júnior, Lucindo José Menezes, Irwin Rose Alencar de Coutinho, Henrique Douglas Melo |
| Issue Date: | 2017 |
| Resumo : | Menadione, vitamin K3, belongs to the class of lipid-soluble vitamins and lipophilic substances as menadione cause disturbances in the bacterial membrane, resulting in damage to the fundamental elements for the integrity of the membrane, thus allowing increased permeability. Accordingly, the aim of this study was to evaluate in vitro the antibiotic-modifying activity of menadione in multiresistant strains of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli, with a gradual increase in its subinhibitory concentration. In addition, menadione was compared with cholesterol and ergosterol for similarity in mechanism of drug modulatory action. Antibiotic-modifying activity and antibacterial effect were determined by the broth microdilution assay. Menadione, cholesterol and ergosterol showed modulatory activity at clinically relevant concentrations, characterizing them as modifiers of bacterial drug resistance, since they lowered the MIC of the antibiotics tested. This is the first report of the antibacterial activity of menadione and its potentiation of aminoglycosides against multiresistant bacteria. |
| Keywords: | Menadione Lipid solubility Microdilution Antibiotic-modifying Permeabilization |
| ISSN: | 2213-7106 |
| Is part of: | Saudi Journal of Biological Sciences |
| Language: | eng |
| Publisher / Institution : | Elsevier: King Saud University |
| Citation: | ANDRADE, J. C. et al. Menadione (vitamin K) enhances the antibiotic activity of drugs by cell membrane permeabilization mechanism. Saudi Journal of Biological Sciences, Amsterdam, v. 24, n. 1, p. 59-64, 2017. DOI: https://doi.org/10.1016/j.sjbs.2015.09.004. Disponível em: https://www.sciencedirect.com/science/article/pii/S1319562X15001990?via%3Dihub. Acesso em: 20 ago. 2026. |
| License: | Creative Commons Atribuição-Não Comercial-Sem Derivações 4.0 Internacional (CC BY-NC-ND 4.0) |
| Identifier: | https://doi.org/10.1016/j.sjbs.2015.09.004 |
| URI: | https://ri.ufs.br/jspui/handle/riufs/25834 |
| Appears in Collections: | DFS - Artigos de periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| MenadioneEnhancesAntibioticActivityDrugs.pdf | 522,8 kB | Adobe PDF |  View/Open |
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