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Tipo de Documento:	Artigo
Título :	Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance
Autor :	Araújo-Santos, Théo de Andrade, Bruno de Bezerril Santana, Leonardo Gil Luz, Nívea Farias Santos, Priscila Lima dos Oliveira, Fabricia Alvisi de Almeida, Meirielly Lima Campos, Roseane Nunes de Santana Bozza, Patricia Torres Almeida, Roque Pacheco de Borges, Valeria de Matos
Fecha de publicación :	2017
Resumen:	Visceral leishmaniasis (VL) remains a major public health problem worldwide. Cytokine balance is thought to play a critical role in the development of this disease. Here, we perform a prospective exploratory study addressing whether simultaneous assessment of circulating levels of different lipid mediators and cytokines could highlight specific pathways involved with VL pathogenesis. VL patients displayed substantial increases in serum levels of Prostaglandin F2α (PGF2α), Leukotriene B4 (LTB4), Resolvin D1 (RvD1), IL-1β, IL-6, IL-8, IL-10, IL-12p70 and TNF-α compared with uninfected endemic control group, while exhibiting decreased levels of TGF-β1. Hierarchical cluster analysis of the prospective changes in the expression level of theses parameters upon anti-Leishmania treatment initiation revealed that the inflammatory profile observed in active disease gradually changed over time and was generally reversed at day 30 of therapy. Furthermore, not only the individual concentrations of most of the inflammatory biomarkers changed upon treatment, but the correlations between those and several biochemical parameters used to characterize VL disease activity were also modified over time. These results demonstrate that an inflammatory imbalance hallmarks active VL disease and open perspective for manipulation of these pathways in future studies examining a potential host-directed therapy against VL.
Palabras clave :	Visceral leishmaniasis Cytokine balance Anti-parasite therapy Inflammatory imbalance
ISSN :	2045-2322
Es parte de:	Scientific reports
Idioma :	eng
Institución / Editorial :	Springer Nature
Citación :	ARAÚJO-SANTOS, T. et al. Anti-parasite therapy drives changes in human visceral leishmaniasis-associated inflammatory balance. Scientific reports, London, v. 7, n. 4334, 2017. DOI: https://doi.org/10.1038/s41598-017-04595-8. Disponível em: https://www.nature.com/articles/s41598-017-04595-8. Acesso em: 24 ago. 2026.
License:	Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)
Identificador:	https://doi.org/10.1038/s41598-017-04595-8
URI :	https://ri.ufs.br/jspui/handle/riufs/25874
Aparece en las colecciones:	DME - Artigos de periódicos

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