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https://ri.ufs.br/jspui/handle/riufs/25877| Document Type: | Artigo |
| Title: | The correlation between chemical structures and antioxidant, prooxidant, and antitrypanosomatid properties of flavonoids |
| Authors: | Baldim, João Luiz Alcântara, Bianca Gonçalves Vasconcelos de Domingos, Olívia da Silva Soares, Marisi Gomes Caldas, Ivo Santana Novaes, Rômulo Dias Oliveira, Tiago Branquinho Lago, João Henrique Ghilardi Chagas-Paula, Daniela Aparecida |
| Issue Date: | 2017 |
| Resumo : | Flavonoids have demonstrated in vivo and in vitro leishmanicidal, trypanocidal, antioxidant, and prooxidant properties. Thechemotherapy of trypanosomiasis and leishmaniasis lacks efficacy, presents high toxicity, and is related to the development ofdrug resistance. Thus, a series of 40 flavonoids were investigated with the purpose of correlating these properties via structureand activity analyses based on integrated networks and QSAR models. The classical groups for the antioxidant activity offlavonoids were combined in order to explain the influence of antioxidant and prooxidant activities on the antiparasiticproperties. These analyses become useful for the development of efficient treatments for leishmaniasis and trypanosomiasis.Finally, the dual activity of flavonoids presenting both anti- and prooxidant activities revealed that the existence of a balancebetween these two features could be important to the development of adequate therapeutic strategies. |
| Keywords: | Flavonoids Chemical structures Drug resistance Prooxidant activities Antioxidant activities |
| ISSN: | 1942-0994 |
| Is part of: | Oxidative Medicine and Cellular Longevity |
| Language: | eng |
| Publisher / Institution : | Hindawi Publishing Corporation |
| Citation: | BALDIM, J. L. et al. The correlation between chemical structures and antioxidant, prooxidant, and antitrypanosomatid properties of flavonoids. Oxidative Medicine and Cellular Longevity, New York, n. 1, 2017. DOI: https://doi.org/10.1155/2017/3789856. Disponível em: https://onlinelibrary.wiley.com/doi/10.1155/2017/3789856. Acesso em: 24 ago. 2026. |
| License: | Creative Commons Atribuição 4.0 Internacional (CC BY 4.0) |
| Identifier: | https://doi.org/10.1155%2F2017%2F3789856 |
| URI: | https://ri.ufs.br/jspui/handle/riufs/25877 |
| Appears in Collections: | DFA - Artigos de periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| CorrelationChemicalStructuresAntioxidantPropertiesFlavonoids.pdf | 824,24 kB | Adobe PDF |  View/Open |
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