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Document Type:	Artigo
Title:	Reduction of the DNA damages, hepatoprotective effect and antioxidant potential of the coconut water, ascorbic and caffeic acids in oxidative stress mediated by ethanol
Authors:	Bispo, Vanderson da Silva Dantas, Lucas Souza Chaves Filho, Adriano de Britto Pinto, Isabella Fernanda Dantas Silva, Railmara Pereira da Otsuka, Felipe Akihiro Melo Santos, Rodrigo Brito Santos, Aline C. Trindade, Danielle J. Matos, Humberto Reis
Issue Date:	2017
Resumo :	Hepatic disorders such as steatosis and alcoholic steatohepatitis are common diseases that affect thousands of people around the globe. This study aims to identify the main phenol compounds using a new HPLCESI+ -MS/MS method, to evaluate some oxidative stress parameters and the hepatoprotective action of green dwarf coconut water, caffeic and ascorbic acids on the liver and serum of rats treated with ethanol. The results showed five polyphenols in the lyophilized coconut water spiked with standards: chlorogenic acid (0.18 µM), caffeic acid (1.1 µM), methyl caffeate (0.03 µM), quercetin (0.08 µM) and ferulic acid (0.02 µM) isomers. In the animals, the activity of the serum γ-glutamyltranspeptidase (γ-GT) was reduced to 1.8 I.U/L in the coconut water group, 3.6 I.U/L in the ascorbic acid group and 2.9 I.U/L in the caffeic acid groups, when compared with the ethanol group (5.1 I.U/L, p<0.05). Still in liver, the DNA analysis demonstrated a decrease of oxidized bases compared to ethanol group of 36.2% and 48.0% for pretreated and post treated coconut water group respectively, 42.5% for the caffeic acid group, and 34.5% for the ascorbic acid group. The ascorbic acid was efficient in inhibiting the thiobarbituric acid reactive substances (TBARS) in the liver by 16.5% in comparison with the ethanol group. These data indicate that the green dwarf coconut water, caffeic and ascorbic acids have antioxidant, hepatoprotective and reduced DNA damage properties, thus decreasing the oxidative stress induced by ethanol metabolism.
Keywords:	Coconut water Ethanol Oxidative stress Phenolic compounds
ISSN:	1678-2690
Is part of:	Anais da Academia Brasileira de Ciências
Language:	eng
Publisher / Institution :	Academia Brasileira de Ciências
Citation:	BISPO, V. S. et al. Reduction of the DNA damages, hepatoprotective effect and antioxidant potential of the coconut water, ascorbic and caffeic acids in oxidative stress mediated by ethanol. Anais da Academia Brasileira de Ciências, Rio de Janeiro, v. 89, n. 2, p. 1095–1109, 2017. DOI: https://doi.org/10.1590/0001-3765201720160581. Disponível em: https://www.scielo.br/j/aabc/a/LznHjX3nszhTZtHDdsZLWkH/abstract/?lang=en. Acesso em: 26 ago. 2026.
License:	Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)
Identifier:	https://doi.org/10.1590/0001-3765201720160581
URI:	https://ri.ufs.br/jspui/handle/riufs/25897
Appears in Collections:	DFS - Artigos de periódicos

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