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https://ri.ufs.br/jspui/handle/riufs/25902| Document Type: | Artigo |
| Title: | Passiflora cincinnata extract delays the development of motor signs and prevents dopaminergic loss in a mice model of Parkinson's disease |
| Authors: | Brandão, Luiz Eduardo Mateus Nôga, Diana Aline Morais Ferreira Dierschnabel, Aline Lima Campêlo, Clarissa Loureiro das Chagas Meurer, Ywlliane da Silva Rodrigues Lima, Ramón Hypolito Engelberth, Rovena Clara Galvão Januário Cavalcante, Jeferson Souza Lima, Clésio Andrade Marchioro, Murilo Estevam, Charles dos Santos Santos, José Ronaldo Silva, Regina Helena Ribeiro, Alessandra Mussi |
| Issue Date: | 2017 |
| Resumo : | Passiflora cincinnata Masters is a Brazilian native species of passionflower. This genus is known in the American continentfolk medicine for its diuretic and analgesic properties. Nevertheless, few studies investigated possible biological effects of P.cincinnata extracts. Further, evidence of antioxidant actions encourages the investigation of possible neuroprotective effects inanimal models of neurodegenerative diseases. This study investigates the effect of the P. cincinnata ethanolic extract (PAS) on micesubmitted to a progressive model of Parkinson’s disease (PD) induced by reserpine. Male (6-month-old) mice received reserpine(0.1 mg/kg, s.c.), every other day, for 40 days, with or without a concomitant treatment with daily injections of PAS (25 mg/kg,i.p.). Catalepsy, open field, oral movements, and plus-maze discriminative avoidance evaluations were performed across treatment,and immunohistochemistry for tyrosine hydroxylase was conducted at the end. The results showed that PAS treatment delayedthe onset of motor impairments and prevented the occurrence of increased catalepsy behavior in the premotor phase. However,PAS administration did not modify reserpine-induced cognitive impairments. Moreover, PAS prevented the decrease in tyrosinehydroxylase immunostaining in the substantia nigra pars compacta (SNpc) induced by reserpine. Taken together, our resultssuggested that PAS exerted a neuroprotective effect in a progressive model of PD. |
| Keywords: | Parkinson’s disease Passiflora cincinnata Dopaminergic loss Motor signs |
| ISSN: | 1741-4288 |
| Is part of: | Evidence-Based Complementary and Alternative Medicine |
| Language: | eng |
| Publisher / Institution : | Hindawi Publishing Corporation |
| Citation: | BRANDÃO, L. E. M. et al. Passiflora cincinnata extract delays the development of motor signs and prevents dopaminergic loss in a mice model of Parkinson's disease. Evidence-Based Complementary and Alternative Medicine, New York, n. 1, 2017. DOI: https://doi.org/10.1155%2F2017%2F8429290. Disponível em: https://onlinelibrary.wiley.com/doi/10.1155/2017/8429290. Acesso em: 26 ago. 2026. |
| License: | Creative Commons Atribuição 4.0 Internacional (CC BY 4.0) |
| Identifier: | https://doi.org/10.1155/2017/8429290 |
| URI: | https://ri.ufs.br/jspui/handle/riufs/25902 |
| Appears in Collections: | DFS - Artigos de periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| PassifloracincinnataExtractMotorSignsParkinsons.pdf | 1,72 MB | Adobe PDF |  View/Open |
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