Please use this identifier to cite or link to this item:
https://ri.ufs.br/jspui/handle/riufs/26064| Document Type: | Artigo |
| Title: | Role of new immunophenotypic markers on prognostic and overall survival of acute myeloid leukemia: a systematic review and meta-analysis |
| Authors: | Costa, Amanda Fernandes de Oliveira Menezes, Daniel Lima Pinheiro, Lúcio Henrique Sousa Sandes, Alex Freire Nunes, Marco Antonio Prado Lyra Junior, Divaldo Pereira Schimieguel, Dulce Marta |
| Issue Date: | 2017 |
| Resumo : | Despite technological advances, the prognosis and survival of acute myeloid leukemia (AML) adult patients remain low, compared with other hematologic malignancies. Some antigens detected by immunophenotyping may soon play a significant role in the pathophysiologic, prognostic, and overall survival (OS) rate of AML patients. Therefore, we conducted a systematic review and meta-analysis of PubMed, Scopus, Science Direct, Web of Science, and the Cochrane Library (using PRISMA guidelines). We analyzed 11 studies and 13 antigens, detected through the immunophenotyping of 639 patients. From them, twelve exhibited a negative impact with AML prognosis. The meta-analysis demonstrated a high expression of AML markers, which have been associated with a decrease in survival over 10 months (RR 2.55; IC 95%; 1.49–4.37) and over 20 months (RR 2.46; IC 95%; 1.75–3.45). Knowing that the expression of immunophenotypic markers, which are not used on a routine basis, might be able to influence disease behavior, looks promising. However, they have been associated with a poor prognosis as well as a decrease in survival. This may allow for different chemotherapeutical protocols, including future studies for new therapeutic targets. |
| Keywords: | Acute myeloid leukemia Prognostic Immunophenotypic markers |
| ISSN: | 2045-2322 |
| Is part of: | Scientific reports |
| Language: | eng |
| Publisher / Institution : | Nature Publishing Group |
| Citation: | COSTA, A. F. O. et al. Role of new immunophenotypic markers on prognostic and overall survival of acute myeloid leukemia: a systematic review and meta-analysis. Scientific reports, London, v. 7, n. 4138, 2017. DOI: https://doi.org/10.1038/s41598-017-00816-2. Disponível em: https://www.nature.com/articles/s41598-017-00816-2. Acesso em: 9 set. 2026. |
| License: | Creative Commons Atribuição 4.0 Internacional (CC BY 4.0) |
| Identifier: | https://doi.org/10.1038/s41598-017-00816-2 |
| URI: | https://ri.ufs.br/jspui/handle/riufs/26064 |
| Appears in Collections: | DFA - Artigos de periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| RoleImmunophenotypicMarkersAcuteMyeloidLeukemia.pdf | 1,91 MB | Adobe PDF |  View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.