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Document Type:	Artigo
Title:	Antinociceptive effect of the essential oil from Croton conduplicatus Kunth (Euphorbiaceae)
Authors:	Oliveira Júnior, Raimundo Gonçalves de Ferraz, Christiane Adrielly Alves Silva, Juliane Cabral Oliveira, Ana Paula de Diniz, Tâmara Coimbra Silva, Mariana Gama e Quintans Júnior, Lucindo José Souza, Ana Valéria Vieira de Santos, Uiliane Soares dos Turatti, Izabel Cristina Casanova Lopes, Norberto Peporine Lorenzo, Vitor Prates Almeida, Jackson Roberto Guedes da Silva
Issue Date:	2017
Resumo :	Medicinal plants have been widely used in the treatment of chronic pain. In this study, we describe the antinociceptive effect of the essential oil from Croton conduplicatus (the EO 25, 50, and 100 mg/kg, i.p.), a medicinal plant native to Brazil. Antinociceptive activity was investigated by measuring the nociception induced by acetic acid, formalin, hot plate and carrageenan. A docking study was performed with the major constituents of the EO (E-caryophyllene, caryophyllene oxide, and camphor). The EO reduced nociceptive behavior at all doses tested in the acetic acid-induced nociception test (p < 0.05). The same was observed in both phases (neurogenic and inflammatory) of the formalin test. When the hot-plate test was conducted, the EO (50 mg/kg) extended the latency time after 60 min of treatment. The EO also reduced leukocyte migration at all doses, suggesting that its antinociceptive effect involves both central and peripheral mechanisms. Pretreatment with glibenclamide and atropine reversed the antinociceptive effect of the EO on the formalin test, suggesting the involvement of KATP channels and muscarinic receptors. The docking study revealed a satisfactory interaction profile between the major components of the EO and the different muscarinic receptor subtypes (M2, M3, and M4). These results corroborate the medicinal use of C. conduplicatus in folk medicine.
Keywords:	Pain Medicinal plants Essential oil Terpenoids
ISSN:	1420-3049
Is part of:	Molecules
Language:	eng
Publisher / Institution :	MDPI
Citation:	OLIVEIRA JÚNIOR, R. G. et al. Antinociceptive effect of the essential oil from Croton conduplicatus Kunth (Euphorbiaceae). Molecules, Basel, v. 22, n. 6, 2017. DOI: https://doi.org/10.3390/molecules22060900. Disponível em: https://pmc.ncbi.nlm.nih.gov/articles/PMC6152674/. Acesso em: 15 set. 2026.
License:	Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)
Identifier:	https://doi.org/10.3390/molecules22060900
URI:	https://ri.ufs.br/jspui/handle/riufs/26113
Appears in Collections:	DFS - Artigos de periódicos

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