1. Repositório Institucional da Universidade Federal de Sergipe - RI/UFS
2. TRABALHOS ACADÊMICOS
3. TRABALHOS DE GRADUAÇÃO
4. Farmácia

Tipo de Documento:	Monografia
Título :	Pharmacological validation of the free-exploratory paradigm in Wistar rats : a proposed test of trait anxiety
Autor :	Souza, Thiago Henrique Almeida
Fecha de publicación :	22-sep-2014
Director(a):	Silva, Flávia Teixeira
Resumen:	The free-exploratory paradigm (FEP) has been proposed as a model of trait anxiety for both mice and rats. However, its pharmacological validation has only been carried out for mice. Thus, the aim of the present study was to pharmacologically validate FEP for Wistar rats, by testing the effects of clinically established anxiolytic and anxiogenic drugs, in four different experiments. In all experiments, male Wistar rats were first tested in FEP to be categorized according to their levels of trait anxiety (high, medium and low). Then, only medium trait anxiety rats were selected to be tested again in FEP, two weeks later, after being pharmacologically treated, according to each experiment as follows: Experiment I: 0.5 mg/kg of diazepam (DZP) or vehicle; Experiment II: 20 mg/kg of pentylenetetrazole (PTZ) or vehicle; Experiment III: 5 mg/kg of fluoxetine (FLX5) or vehicle: and Experiment IV: 0.5 mg/kg of fluoxetine (FLX0.5) or vehicle. As a group, the results showed that PTZ and FLX5 increased levels of trait anxiety and reduced locomotor activity, whereas DZP and FLX0.5 decreased levels of trait anxiety, without impairing locomotor activity. These results demonstrate that FEP for rats is able to predict clinical anxiolytic and anxiogenic activities of different drugs, including fluoxetine, which is believed to present a dual effect on anxiety. Therefore, this paradigm can be proposed as an effective method for testing potential trait anxiety-reducing drugs, in rats.
Palabras clave :	Farmácia Ensino de farmácia
Idioma :	por
Institución:	Universidade Federal de Sergipe
Departamento:	DFA - Departamento de Farmácia – São Cristóvão - Presencial
Citación :	SOUZA, Thiago Henrique Almeida. Pharmacological validation of the free-exploratory paradigm in Wistar rats : a proposed test of trait anxiety. 2015. 1 CD-ROM Monografia (Bacharelado em Farmácia) - Departamento de Farmácia, Centro de Ciências Biológicas e da saúde, Universidade Federal de Sergipe, São Cristóvão, SE, 2015.
URI :	https://ri.ufs.br/handle/riufs/6857
Aparece en las colecciones:	Farmácia

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