Status auditivo em indivíduos com deficiência isolada do hormônio do crescimento

Abstract

Introduction: IGF-1, the main circulating effector of growth hormone (GH) action, is essential for the differentiation, survival and maturation of cells and inner ear. GH isolated congenital deficiency (DIGH) represents an ideal model to study the impact of GH / IGF-1 on the auditory axis. Here we present the auditory status 24 of adult individuals with DIGH, all belonging to a Brazilian population with a homozygous mutation in the hormone releasing hormone receptor gene. growth (GHRHR) Study model: Transversal Objective: To evaluate the auditory status of individuals with DIGH. Materials and methods: In 26 adult subjects with DIGH (47.6 years of age ± 15.1, 13 women) and 25 controls (46.3 years of age ± 14.3, 15 women). a questionnaire on hearing complaints and history of hearing health. Exams as Tonal audiometry, logoaudiometry, electroacoustic immittance and stapedian reflex, transient evoked otoacoustic emissions (TEOAE), emission distortion products (DPOAE) and auditory brainstem evoked potential (BAEP or BERA) were performed aiming at a better analysis of the auditory system. Results: Misfonia and dizziness were the most frequent complaints in the DIGH group (p = 0.011). In tonal audiometry, subjects with DIGH presented higher thresholds (p = 0.008), 4 (p = 0.038), 6 (p = 0.008) and 8 KHz (p = 0.008) (p = 0.048), and hearing loss at higher frequencies (p = 0.029). Stapedian reflex (p <0.001) and TEOAE (p <0.001) were more frequent in controls. There were no differences in DPOAE and BERA thresholds. Hearing loss occurred earlier in the DIGH than in the controls. Conclusion: Individuals with DIGH present more misofonia and dizziness, hearing loss with predominance in higher frequencies and absence of reflex stapedian and TEOAE