Please use this identifier to cite or link to this item: http://ri.ufs.br/jspui/handle/riufs/10384
Document Type: Monografia
Title: Antinociceptive effect of Aristolochia trilobata stem essential oil and 6-methyl-5-hepten-2-yl acetate, its main compound, in rodents
Authors: Alves, Rafael dos Santos
Issue Date: 9-Nov-2016
Advisor: Guimarães, Adriana Gibara
Abstract: Aristolochia trilobata L. is an aromatic plant, popularly known as „mil-homens?, and its essential oil is generally used to treat colic, diarrhea, and dysentery disorders. We evaluated the antinociceptive effect of A. trilobata stem essential oil (EO) and of its major compound, the (R)-(-)-6-methyl-5-hepten-2-yl acetate (sulcatyl acetate: SA), using acetic acid (0.65%)-induced writhing response and formalin -induced (20 µl of 2,5%) nociceptive behavior in mice. We also evaluated the EO and SA effect on motor coordination, using the rota-rod apparatus. EO (25, 50 and 100 mg/kg) or SA (25 and 50 mg/kg) reduced nociceptive behavior in the writhing test (p < 0.001). EO (100 mg/kg) and SA (25 and 50 mg/kg) decreased the nociception on first phase of formalin test (p < 0.05). On second phase, EO(25: p < 0.01; 50: p < 0.05 and 100 mg/kg: p < 0.001) and SA (25 and 50 mg/kg; p < 0.001) reduced the nociceptive response induced by formalin. EO and SA were not able to cause changes in the motor coordination of animals. Together, our results suggest that the EO has an analgesic profile and SA seems to be one of the active compounds in this effect
Keywords: Farmácia
Ensino de farmácia
Aristoloquiácea
Plantas aromáticas
Essencias
Óleos essenciais
Dor
Subject CNPQ: CIENCIAS BIOLOGICAS::FARMACOLOGIA::FARMACOLOGIA CLINICA
Language: por
Institution: Universidade Federal de Sergipe
Department: DFA - Departamento de Farmácia – São Cristóvão - Presencial
Citation: ALVES, Rafael dos Santos. Antinociceptive effect of Aristolochia trilobata stem essential oil and 6-methyl-5-hepten-2-yl acetate, its main compound, in rodents. São Cristóvão, SE, 2016. Monografia (Graduação em Farmácia) - Departamento de Farmácia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Sergipe, São Cristóvão, 2016
URI: http://ri.ufs.br/jspui/handle/riufs/10384
Appears in Collections:Farmácia

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