Please use this identifier to cite or link to this item: http://ri.ufs.br/jspui/handle/riufs/10707
Document Type: Monografia
Title: Host-guest inclusion complex containing β-cyclodextrin and (-)-myrtenol modulates hyperalgesia, anxiety, cognitive alterations and reduce oxidative stress in a mice fibromyalgia like model
Authors: Anjos, Klécia Santos dos
Issue Date: 21-Mar- 218
Advisor: Quintans Júnior, Lucindo José
Abstract: We evaluated anti-hyperalgesic, anxiolytic and antioxidant activity of the complex containing myrtenol (MYR) and β-ciclodextrin (βCD) in fibromyalgia model (FM). The MYR/βCD complex was prepared and structurally characterized. Male Swiss mice were pretreated with MYR (50 mg/kg; p.o.), MYR/βCD (50 mg/kg; p.o.), pregabalin (PGB, 30 mg/kg; i.p) or vehicle. 1h after of treatment, the mechanical hyperalgesia, grip strength test, open field (OF), novel object recognition test (NOR), elevated plus-maze test (EPM) and some oxidative damage markers were assessed. The characterization tests indicated that MYR was incorporated into βCD. MYR/βCD had anti-hyperalgesic effect in all days of treatment and keep this activity during 6 h (p < 0.001). No difference was observed in muscle strength and OF test in MYR/βCD compared with negative control (p > 0.05). In OR test, the group MYR/ βCD spent more time in novel object to the familiar object (p < 0.05). MYR/βCD increase exploration time on open arm (p < 0.05) in EPM. MYR/βCD decrease malondialdehyde amount (p < 0.05), increased catalase activity (p < 0.05) and decreased SOD/CAT ratio when compared to control (p < 0.05). MYR/βCD promotes an anti-hyperalgesia effect for 6 h, revealed anxiolytic-like effect, inhibited cognitive and motor impairment and reduce oxidative stress.
Keywords: Farmácia
Ensino de farmácia
Chronic pain
Fibromyalgia. anxiety
Monoterpene
Cyclodextrin
Oxidative Stress
Subject CNPQ: CIENCIAS DA SAUDE::FARMACIA
Language: por
Institution: Universidade Federal de Sergipe
Department: DFA - Departamento de Farmácia – São Cristóvão - Presencial
Citation: Anjos, Klécia Santos dos. Host-guest inclusion complex containing β-cyclodextrin and (-)-myrtenol modulates hyperalgesia, anxiety, cognitive alterations and reduce oxidative stress in a mice fibromyalgia like model. São Cristóvão, SE, 2018. Monografia (graduação em Farmácia) – Departamento de Farmácia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Sergipe, São Cristóvão, 2018
URI: http://ri.ufs.br/jspui/handle/riufs/10707
Appears in Collections:Farmácia

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