Use este identificador para citar ou linkar para este item:
https://ri.ufs.br/jspui/handle/riufs/10707
Tipo de Documento: | Monografia |
Título: | Host-guest inclusion complex containing β-cyclodextrin and (-)-myrtenol modulates hyperalgesia, anxiety, cognitive alterations and reduce oxidative stress in a mice fibromyalgia like model |
Autor(es): | Anjos, Klécia Santos dos |
Data do documento: | 21-Mar-2018 |
Orientador: | Quintans Júnior, Lucindo José |
Abstract: | We evaluated anti-hyperalgesic, anxiolytic and antioxidant activity of the complex containing myrtenol (MYR) and β-ciclodextrin (βCD) in fibromyalgia model (FM). The MYR/βCD complex was prepared and structurally characterized. Male Swiss mice were pretreated with MYR (50 mg/kg; p.o.), MYR/βCD (50 mg/kg; p.o.), pregabalin (PGB, 30 mg/kg; i.p) or vehicle. 1h after of treatment, the mechanical hyperalgesia, grip strength test, open field (OF), novel object recognition test (NOR), elevated plus-maze test (EPM) and some oxidative damage markers were assessed. The characterization tests indicated that MYR was incorporated into βCD. MYR/βCD had anti-hyperalgesic effect in all days of treatment and keep this activity during 6 h (p < 0.001). No difference was observed in muscle strength and OF test in MYR/βCD compared with negative control (p > 0.05). In OR test, the group MYR/ βCD spent more time in novel object to the familiar object (p < 0.05). MYR/βCD increase exploration time on open arm (p < 0.05) in EPM. MYR/βCD decrease malondialdehyde amount (p < 0.05), increased catalase activity (p < 0.05) and decreased SOD/CAT ratio when compared to control (p < 0.05). MYR/βCD promotes an anti-hyperalgesia effect for 6 h, revealed anxiolytic-like effect, inhibited cognitive and motor impairment and reduce oxidative stress. |
Palavras-chave: | Farmácia Ensino de farmácia Chronic pain Fibromyalgia. anxiety Monoterpene Cyclodextrin Oxidative Stress |
área CNPQ: | CIENCIAS DA SAUDE::FARMACIA |
Idioma: | por |
Sigla da Instituição: | Universidade Federal de Sergipe |
Departamento: | DFA - Departamento de Farmácia – São Cristóvão - Presencial |
Citação: | Anjos, Klécia Santos dos. Host-guest inclusion complex containing β-cyclodextrin and (-)-myrtenol modulates hyperalgesia, anxiety, cognitive alterations and reduce oxidative stress in a mice fibromyalgia like model. São Cristóvão, SE, 2018. Monografia (graduação em Farmácia) – Departamento de Farmácia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Sergipe, São Cristóvão, 2018 |
URI: | http://ri.ufs.br/jspui/handle/riufs/10707 |
Aparece nas coleções: | Farmácia |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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Klecia_Santos_Anjos.pdf | 1,9 MB | Adobe PDF | ![]() Visualizar/Abrir |
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