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dc.contributor.authorOliveira, Fábio S. de-
dc.contributor.authorSantos, Márcio Roberto Viana dos-
dc.contributor.authorAntoniolli, Ângelo Roberto-
dc.contributor.authorMarchioro, Murilo-
dc.identifier.citationOLIVEIRA F. S. et al. Differential effects of lead and zinc on inhibitory avoidance learning in mice. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 34, n. 1, jan. 2001. Disponível em: <>. Acesso em: 08 de set. 2014.pt_BR
dc.description.abstractWe studied the effects of chronic intoxication with the heavy metals lead (Pb2+) and zinc (Zn2+) on memory formation in mice. Animals were intoxicated through drinking water during the pre- and postnatal periods and then tested in the step-through inhibitory avoidance memory task. Chronic postnatal intoxication with Pb2+ did not change the step-through latency values recorded during the 4 weeks of the test (ANOVA, P>0.05). In contrast, mice intoxicated during the prenatal period showed significantly reduced latency values when compared to the control group (day 1: q = 4.62, P<0.05; day 7: q = 4.42, P<0.05; day 14: q = 5.65, P<0.05; day 21: q = 3.96, P<0.05, and day 28: q = 6.09, P<0.05). Although chronic postnatal intoxication with Zn2+ did not alter a memory retention test performed 24 h after training, we noticed a gradual decrease in latency at subsequent 4-week intervals (F = 3.07, P<0.05), an effect that was not observed in the control or in the Pb2+-treated groups. These results suggest an impairment of memory formation by Pb2+ when the animals are exposed during the critical period of neurogenesis, while Zn2+ appears to facilitate learning extinction.pt_BR
dc.publisherBrazilian Journal of Medical and Biological Researchpt_BR
dc.subjectEsquiva inibitóriapt_BR
dc.titleDifferential effects of lead and zinc on inhibitory avoidance learning in micept_BR
dc.identifier.licenseCreative Commons Attribution Licensept_BR
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